Successful treatment of invasive fungal rhinosinusitis caused by Cunninghamella: A case report and review of the literature

Table 1 Invasive fungal rhinosinusitis caused by Cunninghamella reported in English

Ref.	Sex/age	Region	Underlying conditions	Symptoms	Site(s) of involvement	Drug treatment	Surgery	Outcome
Brennan et al[13], 1983	M/70	United States	Diabetes mellitus, sideroblastic anemia, hemochromatosis	Facial pain and palsy, periorbital swelling, hearing loss, visual loss, fever, mental confusion	Nasal sinuses, orbit, brain	Amphotericin B	Orbital decompression, sinus surgery	Died
Chetchotisakd et al[14], 1991	F/68	Thailand	Diabetes mellitus	Headache, left eye pain	Nasal sinuses	Amphotericin B, 5-flucytosine	Sinus surgery	Survived
Kontoyiani et al[15], 1994	M/51	United States	Acute promyelocytic leukemia	Fever, nasal obstruction, dyspnea, fatigue,	Nasal sinuses, lung	Imipenem, vancomycin, trimethoprim- sulfamethoxazole, fluconazole, SCH 39304	No	Died
Ng et al[16], 1994	M/70	Bangladesh	Diabetes mellitus, myelodysplasia	Facial pain, fever, epistaxis	Maxillary sinus	Amphotericin B, rifampin	No	Survived
Jayasuriya et al[17], 2006	M/42	Sri Lanka	None	Periorbital oedema, epiphora	Nasal sinuses	Amphotericin B	No	Survived
Righi et al[18], 2008	M/41	Italy	Acute myeloid leukaemia	Facial swelling, palatal oedema, purulent drainage in the oral cavity	Nasal sinuses, orbit, brain	Amphotericin B	Sinus surgery, Bone marrow transplantation	Died
LeBlanc et al[19], 2013	M/15	United States	Mixed lineage T-cell and myeloid acute leukemia, bone marrow transplantation	Facial pain, fever, epiphora	Nasal sinuses	Amphotericin B	No	Died
Present case, 2017	F/50	China	Acute myeloid leukaemia	Ocular proptosis, pain, visual loss, epiphora, nasal obstruction and rhinorrhea	Nasal sinuses, orbit, lung	Amphotericin B, meropenem, metronidazole, tigecycline, posaconazole	Sinus surgery, orbital decompression, orbital content enucleation	Died due to leukemia relapse