Subcutaneous sarcoidosis of the upper and lower extremities: A case report and review of the literature

Table 1 Subcutaneous sarcoidosis retrospective chart reviews

Authors	Sex	Average age	Serum angiotensin-converting enzyme	Chest X-ray	Most common site of lesion	Most common site of systemic involvement other than the lungs
Ahmed et al[14], 2006	15F/6M	46.3	3/11 Elevated	9/16 Lymphadenopathy, 6/16 Pulmonary infiltration	Upper extremities	Joints-arthritis
Ando et al[15], 2016	8F/1M	52.5	7/9 Elevated	3/9 Lymphadenopathy, 6/9 Lymphadenopathy with pulmonary infiltration	Upper extremities	Eyes
Marcoval et al[7], 2005	9F/1M	52.6	NA	8/10 Lymphadenopathy, 1/10 Lymphadenopathy with pulmonary infiltration	Upper extremities	NA
Marcoval et al[3], 2011	11F/3M	N/A	NA	11/14 Lymphadenopathy, 2/14 Lymphadenopathy with pulmonary infiltration	Upper and lower extremities	Joints-arthritis

Table 2 Features of 25 case reports from 2000-2019

Authors	Sex	Average age	Serum angiotensin-converting enzyme	Chest computed tomography	Chest X-ray	Site of lesion	Extracutaneous involvement other than the lungs
Barnadas et al[16], 2000	F	38	Normal	Normal	Normal	Upper and lower limbs	Malaise, joint pains
Girão et al[17], 2000	M	37	Elevated		Lymphadenopathy	Lower limb	Hands and feet arthralgia
Dalle Vedove et al[18], 2011	1F/1M	75	2/2 Elevated	1/2 Mediastinal Lymphadenopathy, 1/2 Lymphadenopathy with pulmonary infiltration	2/2 Normal	Upper and lower limbs	1/2 Uveitis
Kim et al[19], 2014	M	61	Elevated	Normal		Trunk	Renal
Fichtel et al[20], 2006	F	42	Elevated		Normal	Upper and lower limbs	None
Bosnic et al[21], 2010	F	51	Elevated	Normal		Face	None
Kim et al[22], 2017	M	33		Lymphadenopathy with pulmonary infiltration		Face, toe	None
Won et al[23], 2016	F	54			Normal	Lower limb	None
Marcoval et al[24], 2008	F	49	Elevated		Lymphadenopathy	Upper and lower limbs	None
Dulgueroy et al[25], 2015	F	34	Elevated	Lymphadenopathy with pulmonary infiltration		Face	None
Ruangchaijatuporn et al[26], 2016	M	56		Normal		Lower limb	None
Watanbe et al[27], 2007	F	70	Elevated		Lymphadenopathy	Lower limb	Polyneuropathy of limbs
Janegova et al[28], 2016	F	59		Lymphadenopathy with pulmonary infiltration		Foot	None
Yamaguchi et al[29], 2013	F	85	Elevated	Lymphadenopathy with pulmonary infiltration	Lymphadenopathy	Upper and lower limbs	Joints arthralgia
Mori et al[30], 2018	F	72	Elevated			Lower limb	Renal and cardiac dysfunction
Kwan et al[31], 2015	F	53	Elevated	Lymphadenopathy		Upper and lower limbs	None
Miida et al[32], 2009	F	62	Elevated	Lymphadenopathy with pulmonary infiltration	Lymphadenopathy	Upper limbs	Uveitis, renal dysfunction, splenic nodules
Bianchini et al[33], 2010	F	38	Elevated	Normal	Normal	Face	None
Kerner et al[34], 2008	F	53		Lymphadenopathy	Lymphadenopathy	Upper and lower limbs	Facial nerve palsy, arthralgia
Kim et al[35], 2013	F	52	Elevated	Lymphadenopathy with pulmonary infiltration	Lymphadenopathy	Upper and lower limbs	None
Guccione et al[36], 2017	M	40		Lymphadenopathy		Upper limbs, trunk	None
Meyer-Gonzalez et al[37], 2011	3F	52.6	1/3 Normal, 2/3 Elevated	1/3 Lymphadenopathy, 2/3 Lymphadenopathy with pulmonary infiltration	3/3 Lymphadenopathy	Upper and lower limbs	Dactylitis, lower limb weakness
Moscatelli et al[38], 2011	M	41		Lymphadenopathy with pulmonary infiltration	Normal	Hand	None
Shigemitsu et al[39], 2008	F	65			Lymphadenopathy	Upper extremity	None
Celik et al[40], 2010	F	53	Elevated	Lymphadenopathy with pulmonary infiltration	Lymphadenopathy	Foot	None