Impact of sorafenib on epidural fibrosis: An immunohistochemical study

Table 1 Grading criteria for histopathological assessment of scar tissue by He et al[29]

Grade	Width of the scar tissue
0	No scar tissue in dura mater
1	Thin fibrosis bands present between scar tissue and dura mater
2	Adhesions holding 2/3 of the laminectomy defect present
3	Widespread scar. More than 2/3 of the laminectomy defect affected

Table 2 Microvessels visualized by CD105 immunostaining

Grade	Average number of microvessels (400 x)
1	≤ 3
2	4-6
3	≥ 7

Table 3 Grading of fibrosis and statistical results based on various criteria

		Control (Group 1)		Sorafenib (Group 2)
Assessment measure	Grade	n	%	n	%	P
Fibrosis score	0	0	0	4	50	< 0.001
	1	0	0	4	50
	3	8	100	0	0
Fibroblast density	1	0	0	8	100	< 0.001
	3	8	100	0	0
Inflammatory cell density	1	0	0	6	75	< 0.001
	2	2	25	2	25
	3	6	75	0	0
CD105-stained microvessels	1	0	0	6	75	< 0.001
	2	2	25	2	25
	3	6	75	0	0
Osteopontin-stained microvessels	1	4	50	7	87.5	0.355
	2	2	25	1	12.5
	3	2	25	0	0