Diagnostic value of elevated serum carbohydrate antigen 199 level in acute cholangitis secondary to choledocholithiasis

Table 1 Baseline data of patients

	Observation group (n = 158)	Control group (n = 569)	χ2/t value	P value
Age (yr)	54.31 ± 12.54	51.65 ± 11.29	0.336	0.752
Gender
Male	69	263	0.324	0.569
Female	89	306
B-ultrasound
Diameter of CBD (mm)	9.51 ± 2.14	9.85 ± 2.07	0.243	0.851
Number of CBD
Single	107	372	0.302	0.583
Multiple	51	197
Complications
Diabetes mellitus	32	112	0.025	0.874
Hypertensive disease	36	101	2.049	0.152
Hyperlipidemia	13	41	0.188	0.665
WBC count	8.23 ± 1.82	8.68 ± 2.25	-1.702	0.092

CBD: Common bile duct; WBC: White blood cell.

Table 2 Comparisons of serum liver function indicators

	Observation group (n = 158)	Control group (n = 569)	t value	P value
ALT	127.51 ± 28.71	125.34 ± 27.25	0.235	0.867
AST	130.29 ± 27.87	132.37 ± 30.19	0.229	0.871
TBiL	101.06 ± 23.38	95.49 ± 22.42	0.824	0.206
DBiL	60.62 ± 11.73	55.31 ± 10.82	0.926	0.179
GGT	210.28 ± 43.75	186.35 ± 41.08	1.083	0.126
ALP	237.84 ± 52.97	218.47 ± 50.18	1.024	0.145

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TBiL: Total bilirubin; DBiL: Direct bilirubin; GGT: Glutamyl transpeptidase; ALP: Alkaline phosphatase.

Table 3 Comparisons of tumor markers

	Observation group (n = 158)	Control group (n = 569)	t value	P value
CA199	90.25 ± 21.17	25.19 ± 7.06	25.597	0.000
CA125	26.73 ± 6.94	24.61 ± 6.45	0.527	0.487
CA153	10.07 ± 2.54	9.76 ± 2.24	0.353	0.728
CEA	2.67 ± 0.57	2.53 ± 0.15	0.301	0.779
AFP	3.18 ± 0.63	3.12 ± 0.61	0.208	0.894

CA: Carbohydrate antigen; CEA: Carcinoembryonic antigen; AFP: Alpha fetoprotein.

Table 4 Area under the receiver operating characteristic curve of carbohydrate antigen 199

Area	Std. error	Asymptotic sig.	Asymptotic 95%CI	Cutoff value	Sensitivity	Specificity
0.885	0.022	0.000	0.841-0.929	52.5	0.868	0.816