New tapered metallic stent for unresectable malignant hilar bile duct obstruction

Table 1 Patient background

Case	Sex	Age	Disease	Stent no.	Stenosis morphology	Stenosis length (mm)	Treatment
1	Male	60	Intrahepatic bile duct carcinoma	2	Bismuth II	25	BSC
2	Male	59	Colon cancer	1	Bismuth IIIa	33	Chemotherapy
3	Female	85	Intrahepatic bile duct carcinoma	1	Bismuth IIIa	28	Chemotherapy
4	Female	85	Bile duct carcinoma	2	Bismuth IV	35	BSC
5	Male	67	Intrahepatic bile duct carcinoma	2	Bismuth II	18	Chemotherapy
6	Female	61	Gallbladder cancer	2	Bismuth II	17	BSC
7	Male	65	Gallbladder cancer	1	Bismuth II	18	Chemotherapy
8	Female	85	Gallbladder cancer	2	Bismuth II	22	BSC
9	Male	81	Colon cancer	1	Bismuth II	32	BSC
10	Male	79	Bile duct carcinoma	1	Bismuth IIIa	10	Chemotherapy
11	Male	68	Bile duct carcinoma	1	Bismuth II	12	Chemotherapy

BSC: Best supportive care.

Table 2 Comparison of alanine transaminase values before drainage and after metallic stent insertion

Case	ALT before drainage(IU/L)	ALT after MS insertion(IU/L)	P-value
1	63	54
2	165	26
3	182	32
4	263	53
5	75	14
6	326	52
7	69	25
8	37	25
9	115	25
10	39	22
11	212	35
Average	114.055 ± 96.915	33.00 ± 13.892	P < 0.05

MS: Metallic stent; ALT: Alanine transaminase.

Table 3 Comparison of alkaline phosphatase values before drainage and after metallic stent insertion

Case	ALP before drainage(IU/L)	ALP after MS insertion(IU/L)	P-value
1	1524	1288
2	1113	490
3	1200	386
4	1726	775
5	605	354
6	1289	254
7	1524	956
8	638	256
9	1611	956
10	610	238
11	888	283
Average	1157.09 ± 420.250	566.91 ± 365.157	P < 0.05

MS: Metallic stent; ALP: Alkaline phosphatase.

Table 4 Comparison of T-Bil values before drainage and after metallic stent insertion

Case	T-Bil before drainage(mg/dL)	T-Bil after MS insertion(mg/dL)	P-value
1	13.9	3.8
2	3	1
3	12	1
4	1.4	0.7
5	3.1	0.9
6	10.2	2.1
7	2.3	1.3
8	3	1
9	1.8	1.3
10	3.8	1
11	5.2	1
Average	5.427 ± 4.4365	1.373 ± 0.8833	P < 0.05

MS: Metallic stent.

Table 5 Achievements of metallic stent placement

Case	Survival period (d)	Alive or dead	Patency period (d)	Absence or presence of occlusion	Occlusion cause	Re-intervention
1	142	Dead	126	+	Ingrowth	PS
2	122	Dead	86	+	Ingrowth	PS
3	213	Dead	213	-	-	-
4	93	Dead	93	-	-	-
5	245	Dead	245	-	-	-
6	78	Dead	78	-	-	-
7	533	Alive	130	+	Overgrowth	MS
8	123	Dead	123	-	-	-
9	145	Dead	75	+	Overgrowth	MS
10	127	Dead	127	-	-	-
11	305	Dead	305	-	-	-
Mean	142		208.401	-	-	-
Median	193.273		-	-	-	-

MS: Metallic stent; PS: Plastic stent.