Cabazitaxel in castration resistant prostate cancer with brain metastases: 3 case reports

Table 1 Patient characteristic

	Patient 1	Patient 2	Patient 3
Age (yr)	70	70	72
Comorbidities	Hypertension	Hypertension	Diabetes
Primary treatment	Hormonal therapy	Hormonal therapy	Surgery and radiation therapy
Gleason score	8 (4 + 4)	8 (4 + 4)	8 (5 + 3)
PSA at baseline1 (ng/mL)	158	82	17
ADT time (mo)	38	36	50
Docetaxel cycles	12	8	8
PSA pre- cabazitaxel (ng/mL)	95	292	140
Sites of metastases	Bone, lung, brain	Bone, lung, brain	Bone, liver, brain
Cabazitaxel cycles	12	8	10
Best response	PR on brain and lung	PR on brain and lung	CR on liver and brain
Toxicities	Anemia grade 1, asthenia grade 2	Nausea grade 2; neutropenia grade 2	Asthenia grade 2

¹Before primary treatment. ADT: androgen deprivation therapy; PR: Partial response; CR: Complete response.