Eosinophilic chronic rhinosinusitis in East Asians

Table 1 Demographic and clinical characteristics of eosinophilic chronic rhinosinusitis with nasal polyps and non-eosinophilic chronic rhinosinusitis with nasal polyps

	ECRSwNP	NECRSwNP
n (%)	27 (45%)	33 (55%)
Age (yr), mean ± SD	46.93 ± 12.35	40.27 ± 13.47
M/F	20/7	24/9
With AR (%)	74.10%	48.5%
With asthma (%)	18.50%	12.1%
Duration of symptom (yr)	5.50 ± 3.92	8.55 ± 6.93
VAS	4.04 ± 1.01	3.99 ± 1.09
Score of olfactory dysfunction	5.59 ± 2.54	5.21 ± 2.66
Score of polyps	3.59 ± 1.11b	2.06 ± 0.82
Incidence of bilateral polyps	92.6%b	39.9%
Score of disease on CT	14.42 ± 3.84b	9.64 ± 3.37
Serum IgE (kU/L)	236.72 ± 157.77	167.97 ± 176.77
Blood eosinophil count (× 109/L)	0.44 ± 0.24b	0.21 ± 0.11
Blood eosinophil percentage (%)	6.49 ± 3.27b	3.42 ± 1.87
Tissue eosinophil count/HPF	31.56 ± 21.37b	0.91 ± 0.80

^bP < 0.01 vs NECRSwNP. ECRSwNP: Eosinophilic chronic rhinosinusitis with nasal polyps; NECRSwNP: Non-eosinophilic chronic rhinosinusitis with nasal polyps; M/F: Male/female; AR: Allergic rhinitis; VAS: Visual analogue scale; HPF: High power field; CT: Computed tomography.

Table 2 Computed tomography features of eosinophilic chronic rhinosinusitis with nasal polyps and non-eosinophilic chronic rhinosinusitis with nasal polyps

	ECRSwNP(n = 27)	NECRSwNP(n = 33)
Total disease score of sinuses	14.42 ± 3.84b	9.64 ± 3.37
Number of involved sinuses	7.88 ± 1.22b	5.64 ± 1.49
Percentage of involvement in all sinuses	23.1%a	3.0%
Incidence of bilateral diseases in individual sinuses
Frontal	53.8%b	12.1%
Sphenoid	38.5%a	9.1%
Anterior ethmoid	53.8%a	12.1%
Posterior ethmoid	100.0%b	75.8%
Maxillary	96.2%a	69.7%
OMC	69.2%a	36.4%
Score of diseases in individual sinuses
Frontal	1.81 ± 1.51a	0.88 ± 0.91
Sphenoid	1.23 ± 1.28a	0.55 ± 0.76
Anterior ethmoid	3.27 ± 0.90b	2.27 ± 0.87
Posterior ethmoid	3.04 ± 1.04b	1.52 ± 0.95
Maxillary	2.23 ± 0.43	2.15 ± 0.69
OMC	2.85 ± 1.60	2.27 ± 1.20

^aP < 0.05,

^bP < 0.01 vs NECRSwNP. Scoring for sinus diseases on computed tomography (CT): 0 = normal, 1 = partial opacification, and 2 = total opacification; these points are applied to individual sinuses on each side; OMC is graded as 0 = not occluded, or 2 = occluded; deriving a maximum score of 12 per side. ECRSwNP: Eosinophilic chronic rhinosinusitis with nasal polyps; NECRSwNP: Non-eosinophilic chronic rhinosinusitis with nasal polyps; OMC: Ostiomeatal complex.

Table 3 Diagnostic sensitivity and specificity of blood eosinophil count or percentage for eosinophilic chronic rhinosinusitis

Ref.	Blood eosinophil count				Blood eosinophil percentage
	AUC	Cutoff value	Sensitivity	Specificity	AUC	Cutoff value	Sensitivity	Specificity
Zuo et al[52]	0.873	0.16 × 109/L	84.9%	84.4%	0.863	2.05%	89.0%	84.4%
Wang et al[9]	-	-	-	-	0.818	5.65%	79.0%	78.2%
Hu et al[11]	0.871	0.22 × 109/L	74.2%	86.5%	0.864	3.05%	80.3%	75.3%
Sakuma et al[13]	-	-	-	-	0.880	6.00%	97.4%	70.7%

ECRS: Eosinophilic chronic rhinosinusitis; AUC: Area under receiver operating characteristic curve.