Parotid metastasis of rare lung adenocarcinoma: A case report

Table 1 Summary of results documented from literature describing the characteristics of oral soft tissue metastasis from lung cancer (August 1, 1977 to December 31, 2021)

Feature
Total number of papers published	120
CR	111
SC	3
LTE	3
Co	2
RA	1
Total number of patients	122
World-wide distribution of cases, n (%)
Japan	31 (25.8)
India	14 (11.7)
United States	13 (10.8)
China	10 (8.3)
Turkey	9 (7.5)
Italy	7 (5.8)
Korea = United Kingdom	5 (4.2)
Brazil	4 (3.3)
Morocco = Taiwan = France = Greece = Tunisia = Germany = Switzerland = Australia = Spain	2 (1.7)
Israel = Beirut = Bangladesh = Victoria	1 (0.8)
Gender, n (%)
M	100 (82)
F	22 (18)
Average age of patients (range), yr	60.8 (25-87)
Average age of male patients (range), yr	61.4 (25-87)
Average age of female patients (range), yr	58.3 (36-87)
Chief complaint, n (%)
Related to oral health	97 (79.5)
Not related to oral health	22 (18)
Routine check-up	3 (2.5)
Previous history of LC, n (%)	35 (28.7)
No previous history LC, n (%)	78 (63.9)
NA data on previous history of LC, n (%)	9 (7.4)
Associated risk factors, n (%)	66 (54.1)
S	53 (80.3)
A	9 (13.6)
HT	7 (10.7)
As	6 (9.1)
TB	3 (4.5)
Others	15 (27.2)
No risk factors, n (%)	38 (31.1)
NA data on associated risk factors, n (%)	18 (14.8)
Site of metastasis, n (%)
G	51 (41.8)
Max (Ant-6, Post-12, Both-1, SNA-5/R-10, L-5, Both-4, SNA-5)	24 (47)
Mand (Ant-6, Post-9, Both-2, SNA-8/R-8, L-12, Both-2, SNA-3)	25 (49)
SNA-2	2 (4)
T (Ant-6, Base-4, DL-6, SNA-3, Tip-2)	21 (17.2)
To [Palatine-19 (R-10, L-9), Lingual-2]	21 (17.2)
P (R-8, L-4, BL-2)	14 (11.5)
SMG (L-3, R-1, BL-1)	5 (4.1)
Pa	3 (2.5)
Lip (U-1, L-1)	2 (1.6)
BM	1 (0.8)
RMT	1 (0.8)
MS	3 (2.5)
Oral soft tissues as the initial site of metastasis, n (%)
Y	74 (60.6)
N	44 (36.1)
NA	4 (3.3)
Oral soft tissues as the only site of metastasis, n (%)
Y	63 (51.6)
N	54 (44.2)
NA	5 (4.2)
Average time of detection of metastasis from diagnosis of LC	Few days to 10 yr
Most common clinical features, n (%)
Swelling	100 (81.9)
Ulceration	13 (10.6)
Exophytic	12 (9.8)
Pedunculated	10 (8.2)
Nodules	6 (4.9)
Edema	5 (4.2)
Erosive	2 (1.6)
BOP	10 (8.2)
ST = LP = FNP	1 (0.8)
Type of LC, n (%)
AD	46 (37.7)
SCLC	19 (15.6)
MT	17 (13.9)
SCC	10 (8.2)
NSCLC	8 (6.5)
LCC	6 (4.9)
NEC	5 (4.1)
Sa	3 (2.4)
Ha	2 (1.6)
AC	2 (1.6)
AS	2 (1.6)
PI	2 (1.6)
LC Metastasis, n (%)
IL	55 (45.1)
CL	33 (27)
BL	2 (1.6)
NA	32 (26.2)
Treatment aids, n (%)
RT + CH	31 (25.4)
CH	27 (22.1)
RT = SU	12 (9.8)
CH + RT + SU	8 (6.5)
CH + SU	2 (1.6)
SU + Ta = SU = Sy	1 (0.8)
NG	11 (9)
NA	5 (4.1)
RBP	4 (3.3)
STO	2 (1.6)
Death, n (%)	66 (54.1%)
Reasons of death, n (%)
MM	18 (27.2)
DC	18 (27.2)
RF	4 (6.1)
Others	13 (19.7)
NA	13 (19.7)
Average time of death from diagnosis of metastasis	1 wk to 2.5 yr
Partial relief of symptoms, n (%)	1 (0.8)
Favorable prognosis, n (%)	13 (10.6)
TGO, n (%)	5 (4.1)
LFU, n (%)	6 (4.9)

A: Alcohol; AC: Acinar cell carcinoma; AD: Adenocarcinoma; AFP: Anterior faucial pillar; Ant: Anterior; AS: Adenosquamous carcinoma; As: Arsenic; BL: Bilateral; BM: Buccal mucosa; BOP: Bleeding on probing; CH: Chemotherapy; CL: Contralateral; Co: Correspondence; CR: Case report; DL: Dorsolateral left; LC: Lung cancer; LCC: Large cell carcinoma; LFU: Lost to follow up; M: Male; MS: Multiple sites; MM: Multiple metastasis; MT: Mesothelioma; N: No; NA: Not available; NEC: Neuroendocrine carcinoma; NG: Not given; NSCLC: Non-small-cell lung carcinoma; P: Parotid; Pa: Palate; Pl: Pleomorphic; Post: Posterior; R: Right; RA: Retrospective analysis; RBP: Refused by patient; RF: Respiratory failure; RMT: Retromolar triagone; S: Smoking; Sa: Sarcomatous; SC: Short communication; SCC: Squamous cell carcinoma; SCLC: Small-cell lung carcinoma; SMG: Submandibular gland; SNA: Site not available; ST: Sore throat; STO: Sent to oncologist; SU: Surgery; Sy: Symptomatic; T: Tongue; TB: Tuberculosis; To: Tonsil; TGO: Treatment going on; Y: Yes. Citation: Gupta S, Jawanda MK, Kedia NB, Deb AR, Ganganna A, Saurabh K, Yadav SK, Yadav AB. Lung cancer metastasis to oral soft tissues; Systematic review of 122 cases. J Clin Exp Dent 2022; 14: e854-e874. Copyright ©2022 Medicina Oral SL[4].