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©The Author(s) 2024.
World J Clin Cases. Oct 6, 2024; 12(28): 6195-6203
Published online Oct 6, 2024. doi: 10.12998/wjcc.v12.i28.6195
Published online Oct 6, 2024. doi: 10.12998/wjcc.v12.i28.6195
Table 1 Comparison of general and surgical characteristics among the three groups of pregnant women
Indicator | Low-dose group (n = 97) | How-dose group (n = 97) | Control group (n = 98) | F/χ2 | P value |
Age (years, mean ± SD) | 32 ± 4 | 33 ± 8 | 33 ± 4 | 0.988 | 0.374 |
BMI (kg/m2, mean ± SD) | 28.8 ± 3.3 | 28.9 ± 2.9 | 29.0 ± 2.8 | 0.159 | 0.853 |
Preoperative Hb (g/L, mean ± SD) | 115 ± 8 | 115 ± 8 | 114 ± 7 | 0.055 | 0.946 |
Parity, n (%) | 1.317 | 0.859 | |||
Primipara | 25 (25.8) | 29 (29.9) | 28 (28.6) | ||
Multipara | 62 (63.9) | 61 (62.9) | 59 (60.2) | ||
Grand multipara | 10 (10.3) | 7 (7.2) | 11 (11.2) | ||
Education level, n (%) | 1.712 | 0.789 | |||
Below college | 21 (21.6) | 21 (21.6) | 24 (24.5) | ||
College and undergraduate | 64 (66.0) | 67 (69.1) | 67 (68.4) | ||
Master and above | 12 (12.4) | 9 (9.3) | 7 (7.1) | ||
Blood loss (mL, mean ± SD) | 372 ± 59 | 373 ± 59 | 361 ± 58 | 1.234 | 0.293 |
Operative time (min, mean ± SD) | 37 ± 8 | 37 ± 8 | 36 ± 8 | 0.222 | 0.801 |
Table 2 Comparison of Visual Analog Scale scores at different time points post-cesarean section among the three groups of pregnant women (scores, mean ± SD)
Time point | Low-dose group (n = 97) | How-dose group (n = 97) | Control group (n = 98) | F/χ2 | P value |
Postoperative 6 hours | 1.8 ± 0.4a | 1.9 ± 0.8a | 2.3 ± 0.6b | 22.358 | < 0.001 |
Postoperative 12 hours | 2.7 ± 0.7a | 2.6 ± 0.7a | 3.3 ± 1.2b | 15.599 | < 0.001 |
Postoperative 24 hours | 3.1 ± 1.0a | 2.7 ± 0.8a,b | 3.5 ± 1.2b | 17.220 | < 0.001 |
Postoperative 48 hours | 2.1 ± 0.6 | 2.1 ± 0.7a | 2.4 ± 1.1 | 4.498 | 0.012 |
Rescue rate, n (%) | 15 (15.5) | 14 (14.4) | 27 (27.6) | 6.705 | 0.035 |
Table 3 Comparison of Edinburgh Postnatal Depression scale scores at different time points among the three groups of pregnant women (scores, mean ± SD)
Time point | Low-dose group (n = 97) | How-dose group (n = 97) | Control group (n = 98) | F value | P value |
Prenatal 1 day | 7.5 ± 2.2 | 7.2 ± 2.3 | 7.3 ± 2.3 | 0.245 | 0.783 |
Postoperative 2 day | 7.2 ± 2.2a | 7.5 ± 2.6a | 8.8 ± 3.4b | 8.331 | < 0.001 |
Postoperative 7 day | 7.3 ± 3.1a | 7.0 ± 2.9a | 9.1 ± 3.3b | 13.639 | < 0.001 |
Postoperative 42 day | 8.3 ± 3.1 | 8.1 ± 3.0 | 8.8 ± 3.6 | 1.158 | 0.316 |
Table 4 Comparison of postpartum depression incidence at different time points among the three groups of pregnant women, n (%)
Table 5 Comparison of Ramsay scores after intravenous injection of esketamine among the three groups of pregnant women (scores, mean ± SD)
Time point | Low-dose group (n = 97) | How-dose group (n = 97) | Control group (n = 98) | F value | P value |
Mediate injection | 1.92 ± 0.28 | 1.89 ± 0.33 | 1.83 ± 0.37 | 1.47 | 0.23 |
5 minutes post-injection | 3.4 ± 0.6a | 4.8 ± 0.4a,b | 1.8 ± 0.4b | 949.15 | < 0.01 |
15 minutes post-injection | 2.2 ± 0.5a | 3.6 ± 0.6a,b | 1.9 ± 0.3b | 355.18 | < 0.01 |
Immediate postoperative | 2.04 ± 0.20a | 2.08 ± 0.28a | 1.85 ± 0.39 | 17.25 | < 0.01 |
Table 6 Comparison of post-cesarean section recovery indicators among the three groups of pregnant women (hours, mean ± SD)
Table 7 Comparison of the incidence of adverse reactions after intravenous injection of ketamine in three groups, n (%)
Adverse reaction | Administration time | Low-dose group (n = 97) | How-dose group (n = 97) | Control group (n = 98) | χ2 value | P value |
Nausea & vomiting | 0-2 h | 2 (2.1) | 2 (2.1) | 3 (3.1) | 0.278 | 0.870 |
Headache | 0-2 h | 0 (0) | 2 (2.1) | 0 (0) | 4.048 | 0.132 |
Hallucination | 0-2 h | 2 (7.2)a | 9 (9.3)a,b | 0 (0) | 8.949 | 0.011 |
Dizziness | 0-2 h | 7 (7.2) | 7 (7.2) | 2 (2.0) | 3.368 | 0.186 |
Drowsiness | 0-2 h | 6 (10.3)a | 17 (17.5)a,b | 0 (0) | 18.039 | < 0.001 |
Diplopia | 0-2 h | 2 (8)a | 9 (9.3)a,b | 0 (0) | 9.213 | 0.010 |
Shivering | 0-2 h | 5 (5.2) | 3 (3.1) | 6 (6.1) | 1.022 | 0.600 |
Itching | 0-2 h | 0 (0) | 3 (3.1) | 2 (2.0) | 2.851 | 0.240 |
Reaction delay | 0-2 h | 3 (3.1) | 3 (3.1) | 0 (0) | 3.095 | 0.213 |
- Citation: Chen HZ, Gao Y, Li KK, An L, Yan J, Li H, Zhang J. Effect of intraoperative injection of esketamine on postoperative analgesia and postoperative rehabilitation after cesarean section. World J Clin Cases 2024; 12(28): 6195-6203
- URL: https://www.wjgnet.com/2307-8960/full/v12/i28/6195.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v12.i28.6195