Trends and frontiers in signal amplification for aptamer-based tumor detection: A bibliometric analysis

Table 1 Top 10 countries and institutions ranked by publication counts

Rank	Country/institution	Publications	Citations	Average citations	H-index
	Country
1	China	647	20896	32.3	77
2	Iran	53	2514	47.4	30
3	United States	42	1753	41.7	26
4	Spain	13	636	48.9	11
5	South Korea	11	437	39.7	6
6	Japan	7	142	20.3	5
7	Canada	6	274	45.7	6
8	England	6	256	42.7	4
9	Turkey	6	235	39.2	5
10	India	6	83	13.8	5
	Institution
1	Nanjing University	45	2290	50.9	27
2	Chinese Academy of Sciences	40	1605	40.1	21
3	Southwest University	38	1230	32.4	22
4	Qingdao University Science and Technology	36	1247	34.6	22
5	Hunan University	33	1373	41.6	20
6	Central South University	32	1089	34.0	24
7	Nanjing Medical University	22	589	26.8	12
8	Chongqing Medical University	21	548	26.1	11
9	Shanghai University	20	753	37.7	15
10	Sun Yat-Sen University	19	678	35.7	13

Table 2 Top 10 authors and co-cited authors ranked by publication and citation counts

Rank	Author	Counts	Average citations	Country	Co-cited author	Citations
1	Yuan R	33	32.3	China	Hasanzadeh M	221
2	Xiang Y	19	23.2	China	Wang J	121
3	Yang MH	17	33.7	China	Zhang Y	113
4	Wang KM	16	33.2	China	Bi S	102
5	Li GX	14	43.4	China	Wang Y	95
6	Hasanzadeh M	13	56.6	Iran	Li J	87
7	Zhang SS	11	51.5	China	He Y	86
8	Yu JH	10	28.3	China	Ellington AD	84
9	Sun DP	10	50.3	China	Li Y	84
10	Ding SJ	10	56.4	China	Zhang J	83

Table 3 Top 10 journals and co-cited journals ranked by publication and co-citation counts

Rank	Journal	Article count	IF (2023)	Co-cited journal	Citation	IF (2023)
1	Biosensors and Bioelectronics	105	12.6	Biosensors and Bioelectronics	4879	12.6
2	Analytical Chemistry	93	7.1	Analytical Chemistry	4725	7.1
3	Sensors and Actuators. B, Chemical	66	8.4	Journal of the American Chemical Society	1458	15.0
4	Analytica Chimica Acta	51	6.2	Sensors and Actuators. B, Chemical	1373	8.4
5	Talanta	45	6.1	Chemical Communications	1204	4.9
6	Microchimica Acta	43	5.7	Angewandte Chemie- International Edition	974	16.6
7	Analyst	29	4.2	Analytica Chimica Acta	909	6.2
8	Chemical Communications	26	4.9	ACS Applied Materials and Interfaces	853	9.5
9	ACS Applied Materials and Interfaces	19	9.5	Talanta	827	6.1
10	Trends in analytical chemistry: TRAC	13	13.1	Analyst	802	4.2

IF: Impact factor; ACS: American chemical society; TRAC: Trends analytical chemistry.

Table 4 Top 10 co-cited references ranked by citation counts

Rank	Co-cited reference	Citations	DOI	IF (2023)
1	Ellington AD, 1990, Nature, v346, p818	77	10.1038/346818a0	64.1
2	Tuerk C, 1990, Science, v249, p505	70	10.1126/science.2200121	56.9
3	Dirks RM, 2004, Proc Natl Acad Sci USA, v101, p15275	50	10.1073/pnas.0407024101	11.1
4	Shangguan D, 2006, Proc Natl Acad Sci USA, v103, p11838	49	10.1073/pnas.0602615103	11.1
5	Wang S, 2017, Acs Nano, v11, p3943	35	10.1021/acsnano.7b00373	17.1
6	He Y, 2012, Nanoscale, v4, p2054	33	10.1039/c2nr12061e	6.7
7	Zheng TT, 2014, J Am Chem Soc, v136, p2288	32	10.1021/ja500169y	15.0
8	Tan WH, 2013, Chem Rev, v113, p2842	32	10.1021/cr300468w	62.1
9	Bi S, 2017, Chem Soc Rev, v46, p4281	32	10.1039/c7cs00055c	46.2
10	Jiang Y, 2017, Angew Chem Int Edit, v56, p11916	32	10.1002/anie.201703807	16.6

DOI: Digital object identifier; IF: Impact factor.

Table 5 Top 20 author keywords ranked by frequency

Rank	Keyword	Count	Rank	Keyword	Count
1	Aptamer	133	11	Mucin 1	27
2	Electrochemical biosensor	79	12	Biomarker	26
3	Signal amplification	64	13	Cancer cells	24
4	Biosensor	50	14	Cancer	17
5	Aptasensor	48	15	Tumor markers	17
6	Gold nanoparticles	42	16	Circulating tumor cells	16
7	Exosomes	37	17	Nanomaterial	16
8	Hybridization chain reaction	37	18	DNAzyme	15
9	Electrochemistry	35	19	Electrochemiluminescence	15
10	Carcinoembryonic antigen	29	20	Fluorescence	14