Luspatercept enhances hemoglobin levels in a Chinese boy with congenital sideroblastic anemia: A case report

Table 1 Primary clinical characteristics of the patient

Subject	Value
Gender	Male
Age (yr)	4
Complete blood count
WBC (× 109/L)	4.58
RBC (× 1012/L)	3.66
HGB (g/L)	74
PLT (× 109/L)	548
MCV (fL)	68.9
MCH (pg)	20.2
MCHC (g/L)	293
ANC (× 109/L)	1.33
RET (%)	1.47
ARC (× 1012/L)	0.05
ALT (U/L)	31.6
AST (U/L)	40.7
DBIL (µmol/L)	4.1
TBIL (µmol/L)	14.9
LDH (U/L)	215
SF (ng/mL)	228.9
Iron (µmol/L)	44.95
UIBC (µmol/L)	5.06
TIBC (µmol/L)	50.01
ISAT	0.9
EPO (mIU/mL)	16.31
Mature red blood cell lifespan (d)	57
IgG (g/L)	4.95
IgA (g/L)	0.66
IgM (g/L)	1.09
Erythroid lineage cells (%)	35.5
Megakaryocytes	12
Extracellular iron deposits	2+
Sideroblasts (%)	97
Ringed sideroblasts within the erythroblasts (%)	18
Bone marrow PAS positivity (%)	24
Bone marrow PAS positivity index	46
NGS gene	pathogenic mutations in responsible genes not detected

WBC: White blood cells; RBC: Red blood cells; HGB: Hemoglobin; PLT: Platelet; MCV: Mean corpuscular volume; MCH: Mean corpuscular hemoglobin; MCHC: Mean corpuscular hemoglobin concentration; NC: Absolute neutrophil values; RET: Reticulocyte percentage; ARC: Absolute reticulocyte count; RET-HE: Cell hemoglobin content of reticulocyte; ALT: Glutamic-pyruvic transaminase; AST: Glutamic-oxalacetic transaminase; DBIL: Conjugated bilirubin; TBIL: Total bilirubin; LDH: Lactate dehydrogenase; SF: Serum ferritin; Iron: Serum iron levels; UIBC: Unsaturated iron binding capacity; TIBC: Total iron-binding capacity; ISAT: Transferrin saturation; EPO: Serum concentration of erythropoietin; IgG: Immunoglobulin G; IgA: Immunoglobulin A; IgM: Immunoglobulin M; PAS: Periodic acid-schiff stain in nucleated erythrocytes; NGS: Next-generation sequencing.