Impact of transcranial electrical stimulation on serum neurotrophic factors and language function in patients with speech disorders

Table 1 Comparison of serum neurofactors between the two groups before and after intervention (mean ± SD, pg/mL)

Group		Control group (n = 40)	Observation group (n = 41)	t	P value
GDNF	Before the intervention	365.22 ± 39.84	369.71 ± 41.25	0.4981	0.6198
	After the intervention	378.65 ± 40.57a	433.28 ± 48.71a	5.4776
BDNF	Before the intervention	21.88 ± 3.87	20.98 ± 3.65	1.077	0.2848
	After the intervention	23.05 ± 3.54a	30.96 ± 4.15a	9.2186
CNTF	Before the intervention	18.83 ± 3.35	18.91 ± 3.42	0.1063	0.9156
	After the intervention	19.92 ± 3.21a	23.17 ± 3.14a	4.6063
NGF	Before the intervention	19.79 ± 3.11	19.92 ± 3.08	0.189	0.8506
	After the intervention	22.54 ± 3.25a	33.48 ± 4.02a	13.4492

^aP < 0.05, comparison before and after intervention in the group.

CNTF: Ciliary neurotrophic factor; GDNF: Glial cell-derived neurotrophic factor; BDNF: Brain-derived neurotrophic factor; NGF: Nerve growth factor.

Table 2 Comparison of development levels between the two groups before and after intervention (mean ± SD, point)

	Control group (n = 40)		Observation group (n = 41)
	Before the intervention	After the intervention	Before the intervention	After the intervention
Language ability	66.78 ± 5.81	71.83 ± 6.22a	67.01 ± 5.77	79.54 ± 5.69a,b
Functional ability	78.23 ± 5.75	81.34 ± 6.22a	78.17 ± 5.82	85.34 ± 6.11a,b
Human ability	77.13 ± 6.09	80.54 ± 7.11a	76.94 ± 6.13	84.02 ± 6.51a,b
Motor ability	77.25 ± 5.83	80.57 ± 6.94a	77.02 ± 5.93	82.96 ± 5.31a,b
Developmental quotient	58.69 ± 6.34	75.77 ± 7.49a	58.81 ± 6.27	85.64 ± 2.11a,b

^aP < 0.05, comparison before and after intervention in the group.

^bP > 0.05, compared between groups after intervention.

Table 3 Comparison of language function between the two groups before and after intervention (mean ± SD, point)

		Control group (n = 40)	Observation group (n = 41)	t	P value
Reading comprehension	Before the intervention	17.18 ± 2.09	16.85 ± 2.12	0.0146	0.9884
	After the intervention	23.61 ± 2.54a	29.54 ± 1.93a	0.4838	0.6297
Retelling	Before the intervention	11.48 ± 2.62	11.61 ± 2.59	0.4345	0.6649
	After the intervention	15.81 ± 2.04a	19.74 ± 2.05a	4.3645	0
Fluency	Before the intervention	14.38 ± 2.42	14.27 ± 2.45	1.0718	0.2881
	After the intervention	20.68 ± 3.52a	24.97 ± 3.77a	5.7166	0
Writing	Before the intervention	27.49 ± 2.11	28.12 ± 2.08	0.5213	0.6034
	After the intervention	46.12 ± 3.15a	50.54 ± 3.52a	0.1837	0.8546

^aP < 0.05, comparison before and after intervention in the group.