Could there be an interplay between periodontal changes and pancreatic malignancies?

Table 1 Selected studies assessing various methods for detecting bacteria in different types of gastroenterological cancers

Ref.	Types of samples and methods used	Bacteria detected in patients with PC	Types of digestive cancers
Del Castillo et al[36], 2019	16S rRNA gene sequencing was performed on tissue samples (pancreatic duct, duodenum, pancreas), swabs (bile duct, jejunum, stomach), and stool samples	Lactobacillus, Porphyromonas, Fusobacterium, Prevotella	Pancreatic cancer
Torres et al[37], 2015	16S rRNA gene sequencing was performed on saliva samples	Leptotrichia, Porphyromonas	Pancreatic cancer
Vogtmann et al[39], 2020	16S rRNA gene sequencing was performed on saliva samples		Pancreatic adenocarcinoma
Fan et al[43], 2018	16S rRNA gene sequencing was performed on pre-diagnostic oral wash samples	Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans	Pancreatic adenocarcinoma
Farrell et al[47], 2012	16S rRNA gene sequencing was performed on saliva samples	Streptococcus mitis, Granulicatella adiacens, Neisseria elongata	Pancreatic cancer
Tan et al[48], 2022	16S rRNA gene sequencing was performed on oral wash samples, resected cancer tissue and matched normal adjacent tissues	Porphyromonas gingivalis,Firmicutes, Proteobacteria, Neisseria, Haemophilus, Aggregatibacter, Pseudomonas, Sphingomonas Bacteroidota	Pancreatic cancer
Mitsuhashi et al[52], 2015	Genomic DNA was extracted from pancreatic tissues specimens	Fusobacterium	Pancreatic ductal adenocarcinoma
Yamamura et al[53], 2017	Genomic DNA was obtained using a cotton swab in the oral cavity and from cancerous tissues	Fusobacterium	Esophageal, gastric, colorectal, liver and pancreatic cancer
Gaiser et al[58], 2019	Microbial DNA was isolated from cyst fluid and plasma	Fusobacterium nucleatum, Granulicatella adiacens	Pancreatic cystic neoplasms

PC: Pancreatic cancer.