Unveiling the hidden world of gut health: Exploring cutting-edge research through visualizing randomized controlled trials on the gut microbiota

Table 1 The ten most active countries from 2003 to 2022 in research related to randomized controlled trials involving gut microbiota

Ranking	Country	No. of documents	%
1st	China	276	26.01
2nd	United States	254	23.94
3rd	United Kingdom	97	9.14
4th	Netherlands	76	7.16
5th	Italy	61	5.75
5th	South Korea	61	5.75
7h	Canada	60	5.66
8th	Spain	54	5.09
9th	Australia	53	5.00
10th	Denmark	52	4.90

Table 2 The top ten active institutions in research related to randomized controlled trials involving gut microbiota from 2003 to 2022

Ranking	Institute	Country	No. of documents	%
1st	Københavns Universitet	Denmark	38	3.58
2nd	Dankook University	South Korea	35	3.30
3rd	Ministry of Education China	China	30	2.83
4th	Wageningen University & Research	United States	28	2.64
5th	Harvard Medical School	United States	21	1.98
6th	University of Calgary	Canada	20	1.89
7th	Helsingin Yliopisto	Finland	19	1.79
7th	Chinese Academy of Sciences	China	19	1.79
9th	University of California, Davis	United States	18	1.70
10th	INSEM	France	17	1.60
10th	Instituto de Salud Carlos III	Spain	17	1.60

Table 3 The top ten funding agencies that have published the most research on randomized controlled trials involving gut microbiota between 2003 and 2022

Ranking	Funding agencies	Country	No. of documents	%
1st	National Natural Science Foundation of China	China	91	8.58
2nd	National Institutes of Health	United States	67	6.31
3rd	National Institute of Diabetes and Digestive and Kidney Diseases	United States	32	3.02
3rd	National Key Research and Development Program of China	China	32	3.02
5th	European Regional Development Fund	European Union	20	1.89
6th	Instituto de Salud Carlos III	Spain	18	1.70
6th	National Center for Advancing Translational Sciences	United States	18	1.70
8h	National Health and Medical Research Council	Australia	14	1.32
8th	National Research Foundation of Korea	South Korea	14	1.32
10th	National Cancer Institute	United States	13	1.23

Table 4 The leading journals with the most publications in research on randomized controlled trials involving gut microbiota from 2003 to 2022

Ranking	Journal/source title	No. of documents	%	IF1
1st	Nutrients	50	4.71	6.706
2nd	Plos one	26	2.45	3.752
3rd	Scientific Reports	24	2.26	4.996
4th	European Journal of Nutrition	20	1.89	4.865
5th	American Journal of Clinical Nutrition	19	1.79	8.472
5th	Clinical Nutrition	19	1.79	7.643
7th	BMJ Open	18	1.70	3.006
7h	Journal of Nutrition	18	1.70	4.687
9th	Frontiers in Nutrition	17	1.60	6.59
9th	Gut	17	1.60	31.793

¹2021 Journal Citation Reports™ (Clarivate, 2022).

IF: Impact factor.

Table 5 The ten most-cited articles that cited research involving randomized controlled trials on gut microbiota between 2003 and 2022

Ref.	Title	Year	Source title	Cited by	Impact index per article1
Vrieze et al[89], 2012	“Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome”	2012	Gastroenterology	1977	171.0
Moayyedi et al[85], 2015	“Fecal Microbiota Transplantation Induces Remission in Patients With Active Ulcerative Colitis in a Randomized Controlled Trial”	2015	Gastroenterology	1012	116.3
Wu et al[90], 2017	“Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug”	2017	Nature Medicine	892	137.3
Subramanian et al[88], 2014	“Persistent gut microbiota immaturity in malnourished Bangladeshi children”	2014	Nature	773	89.7
Paramsothy et al[86], 2017	“Multidonor intensive fecal microbiota transplantation for active ulcerative colitis: A randomised placebo-controlled trial”	2017	The Lancet	754	118.3
Gareau et al[82], 2010	“Probiotics and the gut microbiota in intestinal health and disease”	2010	Nature Reviews Gastroenterology and Hepatology	596	43.5
Cani et al[81], 2009	“Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal”	2009	American Journal of Clinical Nutrition	534	36.6
Queipo-Ortuño et al[87], 2012	“Influence of red wine polyphenols and ethanol on the gut microbiota ecology and biochemical biomarkers”	2012	American Journal of Clinical Nutrition	481	41.7
Lee et al[84], 2016	“Frozen vs fresh fecal microbiota transplantation and clinical resolution of diarrhea in patients with recurrent clostridium difficile infection a randomized clinical trial”	2016	JAMA-Journal of the American Medical Association	461	62.3
Ianiro et al[83], 2018	“Randomised clinical trial: Faecal microbiota transplantation by colonoscopy vs. vancomycin for the treatment of recurrent Clostridium difficile infection”	2015	Alimentary Pharmacology and Therapeutics	414	47.8

¹The impact index per article is presented based on Reference Citation Analysis (Source: Baishideng Publishing Group Inc. Pleasanton, CA 94566, United States).