Autosomal dominant non-syndromic hearing loss caused by a novel mutation in MYO7A: A case report and review of the literature

Table 1 Summary of the identified DFNA11 variants

Mutation	Exon	Structure	Patient number	Age of onset (yr)	Audiogram	Vestibular symptoms	Family origin	Ref.
c.2656-2664del/A886-K888Del	22	Coiled coil	8/19	12-16	Flat/sloping	Absent	Japan	[8]
c.652G>A/p.D218N	7	Motor domain	11/29	20-47	Flat/sloping	Absent	China	[13]
c.689C>T/p.A230V	7	Motor domain	1 (sporadic case)	4	U-shaped	Absent	Japan	[16]
c.689C>T/p.A230V	7	Motor domain	9/18	Mean 6-7	Flat/sloping	Bilateral areflexia	Italy	[17]
c.1373A>T/p.N458I	13	Motor domain	11/26	4-43	Ascending-flat-sloping	Vertigo and unsteady walking	Netherlands	[18]
c.2003G>A/p.R668H	17	Motor domain	9/15	17-45	Ascending-flat-sloping	-	China	[19]
c.2011G>A/p.G671S	17	Motor domain	9/23	10-39	Ascending-flat-sloping	Absent	China	[13]
c.2011G>A/p.G671S	17	Motor domain	11/29	13-40	Flat/sloping	Absent	China	[20]
c.2164G>C/p.G722R	17	Motor domain	13/43	20-30	Ascending-flat-sloping	Absent	United States	[21]
c.2557C>T/p.R853C	21	IQ 5	5/12	1 mo to puberty	-	Mild dysfunction	Germany	[22]
c.2558G>A/p.A853H	21	IQ 5	12/23	1-33	Flat/sloping	Absent	Japan	[14]
c.1531G>A/p.D511N	13	Motor domain	5/12	35-42	Flat/sloping	Absent	China	This report