Diabetes more than retinopathy, it’s effect on the anterior segment of eye

Table 1 Drugs for the management of diabetic-cornea

No.	Drug	Indication
1	Topical thymosin β4	Non-healing epithelial defect
2	Topical autologous serum	Promote corneal wound healing
3	Topical CT-112	Reduction in corneal barrier effect
4	Topical insulin	Quicker reepithelization after epithelial scraping for vitreoretinal surgeries
5	Topical insulin	Prevent sub-basal nerve plexus loss
6	Topical insulin	Promote wound healing
7	Topical ranirestat	Promote wound healing, control the expression of MMP-10 and integrin α3 expression
8	Injection IGF-1	Prevention of stem cell loss and improve sub-basal nerve plexus density
9	Topical naltrexone	Normalize corneal epithelial wound healing, tear film, and corneal sensations
10	Nateglinide and glibenclamide	Inhibit descemet membrane changes
11	Ciliary neurotrophic factor	Improve epithelial stem cells, increase nerve density and promote epithelial healing
12	Topical nerve growth factor	Reduced apoptosis and inflammation
13	IL-1 antagonists	Reduced apoptosis, faster wound healing, sensory stimulation, improved Akt signaling
14	Substance P	Improved wound healing, reinnervation, and reactivation of EGFR/Akt signaling

MMP: Matrix metalloproteinases; IGF-1: Insulin-like growth factor-1; EGFR: Epidermal growth factor receptor; IL-1: Interleukin-1.