Cardiac amyloidosis presenting as pulmonary arterial hypertension: A case report

Table 1 Previous reports of cases of pulmonary hypertension with amyloidosis

Case	Ref.	Age (year)/sex	Biopsy site	Type of amyloid	MPAP (mmHg)	MM	Treatment	Time to death (mo)
1	Chapman et al[19], 1999	91/F	Lung, heart	AL	NI	(-)	NI	NI
2	Cirulis et al[4], 2016	53/F	Lung, heart	IgGκ AL	46	(+)	Bortezomib-thalidomide-dexamethasone, sildenafil	Survival
3	D'Aloia et al[20], 2008	75/M	Fat, heart	AL	NI	(-)	NI	NI
4	Dingli et al[10], 2001	61/F	BM, fat	IgGκ AL	58	(+)	Diuretics, melphalan, prednisone, cyclophosphamide, vincristine doxorubicin, dexamethasone	1
5	Dingli et al[10], 2001	64/F	BM	IgGλ AL	NI	(+)	Diuretics, vincristine, BCNU, Melphalan, cyclophosphamide, prednisone	29
6	Dingli et al[10], 2001	82/M	BM	IgGλ AL	NI	(-)	Diuretics, digoxin, calcium channel blocker	32
7	Dingli et al[10], 2001	54/F	Lung	IgGκ AL	48	(-)	Diuretics, calcium channel blocker, aspirin	2
8	Dingli et al[10], 2001	48/F	Liver	Amyloid A AL	62	(-)	Calcium channel blocker, colchicine	2
9	Eder et al[8], 2007	73/F	BM	AL	90	(+)	Prednisone, chlorambucil, dexamethasone, cyclophosphamide	8
10	Hashimoto et al[21], 2015	85/F	BM	IgGκ AL	60	(+)	Melphalan-prednisolone, Lenalidomide- dexamethasone, bortezomib, cyclophosphamide, vincristine, and dacarbazine	29
11	Kruczak et al[22], 2013	67/F	Lung, colon mucosa	Transthyretin AL	95	(-)	Methylprednisolone, melphalan and cyclophosphamide	1
12	Lehtonen and Kettunen[23], 2007	48/M	BM, fat	AL	46	(+)	Sildenafil, melphalan, prednison	NI
13	Lutz et al[24], 1995	61/F	Heart, lung	β2M AL	75	(-)	Antihypertensive medication	12
14	Shiue and McNally[25], 1988	65/F	BM, lung, rectal	AL	39	(+)	Melphalan, prednisolone, diuretics	1
15	Sullivan and Schwarz[26], 1994	72/F	BM, lung	AL	56	(+)	NI	6
16	Krishnan et al[27], 2015	69/F	BM, heart, renal	AL	41	(+)	Sildenafil, bumetadine, warfarin, metoprolol succinate, ambrisentan	NI
17	Present case, 2019	51/F	BM, heart, fat	IgGλ AL	51	(-)	Sildenafil, cyclophosphamide, bortezomib, dexamethasone	60

F: Female; M: Male; BM: Bone morrow; MPAP: Mean pulmonary artery pressure; MM: Multiple Myeloma; AL: Light chain amyloid; NI: No information; β2M: Beta-2 microglobulin.