Integrative analysis of platelet-related genes for the prognosis of esophageal cancer

Table 1 Clinical characteristics of all esophageal cancer patients

Variables	Esophageal cancer		Percent
Age in yr
≤ 65		94	62.3
> 65		57	37.7
Sex
Male		129	85.4
Female		22	14.6
Stage
Ⅰ		18	11.9
Ⅱ		70	46.4
Ⅲ		51	33.8
Ⅳ		12	7.9
Grade
G1		16	10.6
G2		60	39.7
G3		41	27.2
Gx		34	22.5
Alcohol consumption
Yes		105	69.5
No		43	28.5
Unknown		3	2.0
Symptoms
Yes		116	76.8
No		10	6.6
Unknown		25	16.6
Pathological type
Squamous cell carcinoma		77	51.0
Adenocarcinoma		74	49.0
Survival status
Alive		93	61.6
Deceased		58	38.4
Smoking-yrs		38.5 (30.0-50.0)
BMI		24.4 (21.2-27.4)
Mean follow-up time in mo		13.4 (7.7-23.1)

BMI: Body mass index.

Table 2 Platelet-related genes in the prognostic classifier associated with overall survival

Gene	Univariate Cox regression analysis			LASSO
	HR	95%CI	P	Coefficient
PLA2G6	0.581	0.343-0.983	0.040	-0.674
EP300	0.543	0.301-0.981	0.040	-0.801
APOOL	1.967	1.186-3.262	0.008	0.739
VAMP7	2.452	1.269-4.740	0.008	0.798

HR: Hazard ratio; CI: Confidence interval; LASSO: Least absolute shrinkage and selection operator.

Table 3 Correlations between risk score of the platelet-related genes and clinicopathological characteristics

Parameters	Risk model		χ2	P
	High risk	Low risk
Age in yr			0.321	0.571
≤ 65	45	49
> 65	30	27
Sex			1.824	0.177
Male	67	62
Female	8	14
Grade			0.188	0.910
G1-2	37	39
G3	20	21
Gx	18	16
Histological type			4.134	0.042
Squamous cell carcinoma	32	45
Adenocarcinoma	43	31
Stage			2.416	0.120
Ⅰ-Ⅱ	39	49
Ⅲ-Ⅳ	36	27