Critical values of monitoring indexes for perioperative major adverse cardiac events in elderly patients with biliary diseases

Table 1 Comparative analysis of clinical data between major adverse cardiac events and non-major adverse cardiac events group in elderly patients with biliary diseases (mean ± SD)

	MACE (n = 9)	Non-MACE (n = 199)	t/Z/χ2 value	P/F value
Age (yr)	76.6 ± 8.6	72.1 ± 8.5	1.559	0.121
Gender				0.738
Men	5	93
Women	4	106
Disease type				1.000
A	7	145
B	8	174
C	0	15
Operation method				0.585
Laparoscopy	8	181
Laparotomy	1	18
Intraoperative blood loss (mL)	56.7 ± 60.2	41.5 ± 81.9	0.547	0.585
Operation time (min)	132.0 ± 78.3	94.5 ± 57.9	1.872	0.063
Postoperative hospital stay (d)	16.0 ± 9.8	9.4 ± 6.3	2.982	0.003
Postoperative complicationsa			-2.828	0.005
I	0	26
II	1	15
III	1	3
IV	5	32
V	2	0
Treatment effect				0.002
Cure	7	199
Death	2	0

^aClavien-Dindo classification of postoperative complications. A: Cholelithiasis; B: Biliary inflammation; C: Biliary tumor; MACE: Major adverse cardiac events.

Table 2 Comparison of monitoring indexes of between the preoperative and postoperative cardiac and coagulation functions in elderly patients with biliary diseases [M (P25, P75)]

Item	Preoperative (n = 208)	Postoperative (n = 208)	Z	P value
HsTn-I (ng/mL)	0.004 (0.002, 0.008)	0.005 (0.003, 0.010)	-2.345	0.019
CKMB (ng/mL)	0.700 (0.500, 1.200)	0.800 (0.500, 1.200)	-2.214	0.027
MYO (ng/mL)	46.700 (30.875, 72.400)	67.850 (41.975, 114.55)	-5.591	0.000
BNP (pg/mL)	76.700 (44.950, 134.525)	152.500 (94.450, 302.675)	-8.777	0.000
D-D (mg/L)	0.330 (0.160, 0.683)	0.510 (0.260, 1.025)	-3.890	0.000
APTT (sec)	31.100 (28.950, 32.900)	30.700 (28.400, 32.700)	-1.512	0.130
PT (sec)	11.900 (11.100, 13.000)	12.300 (11.600, 13.425)	-3.083	0.002
FIB (g/L)	3.710 (3.060, 4.683)	3.625 (2.955, 4.460)	-1.141	0.254

APTT: Activated partial thromboplastin time; BNP: B-type natriuretic peptide; CK-MB: Creatine kinase isoenzyme; D-D: D-dimer; PT: Prothrombin time; FIB: Fibrinogen; Hs-TnI: High sensitivity troponin-I; MYO: Myoglobin.

Table 3 Comparison of monitoring indexes of the postoperative cardiac and coagulation functions between major adverse cardiac events and non-major adverse cardiac events group in elderly patients with biliary diseases [M (P25, P75)]

Item	MACE group (n = 9)	Non-MACE group (n = 199)	Z value	P value
HsTn-I (ng/mL)	0.034 (0.006, 0.112)	0.005 (0.003, 0.009)	-3.078	0.002
CKMB (ng/mL)	2.200 (1.000, 2.500)	0.800 (0.500, 1.150)	-2.896	0.004
MYO (ng/mL)	230.300 (60.200, 454.400)	67.200 (41.700, 109.000)	-2.013	0.044
BNP (pg/mL)	617.400 (200.200, 931.300)	148.900 (93.450, 289.200)	-2.851	0.004
D-D (mg/L)	2.150 (1.060, 2.520)	0.480 (0.250, 0.970)	-3.941	0.000
APTT (sec)	34.500 (28.700, 35.800)	30.650 (28.400, 32.475)	-1.384	0.166
PT (sec)	12.700 (12.000, 19.200)	12.300 (11.600, 13.400)	-1.235	0.217
FIB (g/L)	3.310 (2.850, 3.960)	3.630 (2.965, 4.460)	-0.634	0.526

APTT: Activated partial thromboplastin time; BNP: B-type natriuretic peptide; CK-MB: Creatine kinase isoenzyme; D-D: D-dimer; PT: Prothrombin time; FIB: Fibrinogen; Hs-TnI: High sensitivity troponin-I; MYO: Myoglobin; MACE: Major adverse cardiac events.

Table 4 Multivariate logistic regression analysis of monitoring indexes of the postoperative cardiac and coagulation functions in elderly patients with biliary diseases

Item		SE	Wald	P value	OR	95%CI
BNP	0.003	0.001	3.983	0.046	1.003	1.000-1.005
Hs-TnI	1.781	4.499	0.157	0.692	5.934	0.001-40088.202
D-D	0.849	0.417	4.154	0.042	2.338	1.033-5.290
CKMB	0.025	0.300	0.007	0.934	1.025	0.569-1.847
MYO	0.000	0.002	0.021	0.884	1.000	0.996-1.005
Constant	-5.312	0.893	35.403	0.000	0.005

BNP: B-type natriuretic peptide; CK-MB: Creatine kinase isoenzyme; D-D: D-dimer; Hs-TnI: High sensitivity troponin-I; MYO: Myoglobin.