©The Author(s) 2022.
World J Clin Cases. Jan 14, 2022; 10(2): 717-724
Published online Jan 14, 2022. doi: 10.12998/wjcc.v10.i2.717
Published online Jan 14, 2022. doi: 10.12998/wjcc.v10.i2.717
Table 1 Results of cerebrospinal fluid analysis on admission
| Parameter | Patient’s value | Reference value |
| Color | Light yellow | Clear |
| Xanthochromia | Positive | Negative |
| Cell count (cells/μL) | 484 | 0–3 |
| Monocyte count (cells/μL) | 448 | 0–3 |
| Neutrophil count (cells/μL) | 36 | 0–3 |
| Total protein (mg/dL) | 788 | 10–40 |
| Glucose (mg/dL) | 111 | 50–75 |
| HSV antibody titer (CFT) | Negative | Negative |
| HSV-DNA (PCR) (copies/mL) | Negative | Negative |
| VZV antibody titer (CFT) | 4 | Negative |
| VZV-DNA (PCR) (copies/mL) | 1.4 × 106 | Negative |
Table 2 The patient’s clinical course
| Day | 1 | 9 | 16 | 23 |
| CSF cell count (cells/μL) | 484 | 112 | 119 | 29 |
| CSF VZV antibody titer (CFT) | 4 | 32 | ||
| CSF VZV-DNA (PCR) (copies/mL) | 1.4 × 106 | 3.2 × 102 | (-) | (-) |
| Serum VZV-IgM (EIA) | 0.49 (-) | 0.95 (±) | 0.44 (-) | |
| Serum VZV-IgG (EIA) | 75.9 (+) | > 128 (+) | > 128 (+) |
Table 3 Summary of studies on VZV-associated meningitis, encephalitis, and myelitis
| Case | First Author (yr) | Ref | Age (yr) | Sex | Underlying diseases | Rash | Treatment | Outcome |
| 1 | Mancardi (1987) | 8 | 32 | F | None | None | Acyclovir | Survived |
| 2 | Kleinschmidt-DeMasters (1996) | 9 | 69 | F | Steroid dependent asthma | C8-Th3 distribution zoster | Not reported | Died |
| 3 | Kleinschmidt-DeMasters (1996) | 9 | 36 | M | HIV | None | Not reported | Died |
| 4 | Cinque (1997) | 10 | Not reported | Not reported | HIV | None | Acyclovir | Died |
| 5 | Sissoko (1998) | 11 | 75 | M | None | None | Acyclovir | Survived |
| 6 | Russman (2003) | 12 | 51 | F | Steroid dependent CREST syndrome | None | Acyclovir | Survived |
| 7 | Tavazzi (2008) | 13 | 85 | F | None | None | Acyclovir | Died |
| 8 | Tizazu (2020) | 14 | 53 | F | Steroid dependent SLE | None | Acyclovir | Survived |
| 9 | Takami (2021) | Present case | 64 | M | Mild diabetes mellitus | Four sporadic blisters | Acyclovir | Survived |
- Citation: Takami K, Kenzaka T, Kumabe A, Fukuzawa M, Eto Y, Nakata S, Shinohara K, Endo K. Varicella-zoster virus-associated meningitis, encephalitis, and myelitis with sporadic skin blisters: A case report. World J Clin Cases 2022; 10(2): 717-724
- URL: https://www.wjgnet.com/2307-8960/full/v10/i2/717.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v10.i2.717