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©The Author(s) 2022.
World J Clin Cases. Jan 14, 2022; 10(2): 492-501
Published online Jan 14, 2022. doi: 10.12998/wjcc.v10.i2.492
Published online Jan 14, 2022. doi: 10.12998/wjcc.v10.i2.492
Table 1 Ultrasonographic findings of cervical lymph node metastases in positive and negative patients, n (%)
Pathological results | n | Cortical centripetal thickening | Hypoechogenicity of cortex and medulla | Long diameter/short diameter < 2 | Partial liquefaction or fusion of the lymph nodes | Rich internal blood supply | Hilum deletion | ||||||
Yes | No | Yes | No | Yes | No | Yes | No | Yes | No | Yes | No | ||
Positive cervical lymph node metastasis | 124 | 69 (55.65) | 55 (44.35) | 55 (44.35) | 69 (55.65) | 67 (54.03) | 57 (45.97) | 39 (31.45) | 85 (68.55) | 63 (50.81) | 61 (49.19) | 32 (25.81) | 92 (74.19) |
Negative cervical lymph node metastasis | 85 | 34 (40.00) | 51 (60.00) | 26 (30.59) | 59 (69.41) | 30 (35.29) | 55 (64.71) | 14 (16.47) | 71 (83.53) | 31(36.47) | 54 (63.53) | 11 (12.94) | 74 (87.06) |
χ2 value | 4.939 | 4.027 | 7.120 | 5.980 | 4.188 | 5.108 | |||||||
P value | 0.026 | 0.045 | 0.008 | 0.014 | 0.041 | 0.024 |
Table 2 Comparison of fine-needle aspiration thyroglobulin values between positive and negative patients with cervical lymph node metastasis (mean ± SD)
Pathological results | n | FNA-Tg (ng/mL) | t value | P value |
Positive cervical lymph node metastasis | 124 | 1.56 ± 0.47 | 14.526 | 0.000 |
Negative cervical lymph node metastasis | 85 | 0.77 ± 0.21 |
Table 3 The comparison of pathological diagnosis results between single and combined diagnosis of fine-needle aspiration and fine-needle aspiration thyroglobulin
FNA | Pathological results | Total | FNA-Tg | Pathological results | Total | FNA + FNA-Tg | Pathological results | Total | |||
Positive | Negative | Positive | Negative | Positive | Negative | ||||||
Positive | 106 | 8 | 114 | Positive | 103 | 11 | 114 | Positive | 120 | 7 | 127 |
Negative | 18 | 77 | 95 | Negative | 21 | 74 | 95 | Negative | 4 | 78 | 82 |
Total | 124 | 85 | 209 | Total | 124 | 85 | 209 | Total | 124 | 85 | 209 |
Table 4 Value of fine-needle aspiration and fine-needle aspiration thyroglobulin alone and in combination in the diagnosis of cervical lymph node metastasis in patients with thyroid carcinoma (%)
Diagnostic method | Sensitivity | Specificity | Rate of missed diagnosis | Misdiagnosis rate | Positive predictive value | Negative predictive value |
FNA | 85.48 | 90.59 | 14.52 | 9.41 | 92.98 | 81.05 |
FNA-Tg | 83.06 | 87.06 | 16.94 | 12.94 | 90.35 | 77.89 |
FNA + FNA-Tg | 96.77 | 91.76 | 3.23 | 8.24 | 94.49 | 95.12 |
Table 5 Univariate analysis of influence of fine-needle aspiration thyroglobulin on the single diagnosis of cervical lymph node metastasis in patients with thyroid carcinoma
Index | Correct diagnosis (n = 177) | Error diagnosis (n = 32) | t/χ2 value | P value |
Age (yr) | 49.3 ± 5.8 | 48.2±6.6 | 0.966 | 0.335 |
Gender, n (%) | 0.140 | 0.708 | ||
Male | 67 (37.85) | 11 (34.38) | ||
Female | 110 (62.15) | 21 (65.63) | ||
Short diameter of lymph node (cm) | 0.62 ± 0.11 | 0.60 ± 0.08 | 0.982 | 0.327 |
Long diameter of lymph node (cm) | 1.38 ± 0.20 | 1.29 ± 0.23 | 2.288 | 0.023 |
Long diameter/short diameter, n (%) | 6.965 | 0.008 | ||
< 2 | 88 (49.72) | 24 (75.00) | ||
≥ 2 | 89 (50.28) | 8 (25.00) | ||
Number of collected cells, n (%) | 15.034 | 0.000 | ||
Insufficient | 11 (6.21) | 9 (28.13) | ||
Sufficient | 166 (93.79) | 23 (71.88) | ||
Serum TSH (ng/mL) | 2.09 ± 0.39 | 2.31 ± 0.46 | -2.854 | 0.005 |
Serum TgAb (IU/mL) | 20.83 ± 5.17 | 22.15 ± 5.83 | -1.303 | 0.194 |
Serum Tg (ng/mL) | 18.94 ± 4.20 | 16.84 ± 4.00 | 2.621 | 0.009 |
Number of cervical lymph node metastases | 3.41 ± 0.84 | 3.15 ± 0.76 | 1.634 | 0.104 |
Characteristics of ultrasonic signs, n (%) | 4.885 | 0.027 | ||
Signs of metastasis | 142 (80.23) | 20 (62.50) | ||
No signs of metastasis | 35 (19.77) | 12 (37.50) |
Table 6 Logistic model of the influencing factors in fine-needle aspiration thyroglobulin diagnosis of lymph node metastasis
Factors | SE | Walds | P value | OR | 95%CI | ||
Long diameter of lymph node | 0.611 | 0.412 | 2.199 | 0.138 | 1.842 | 0.822 | 4.131 |
Long diameter/short diameter | 0.741 | 0.338 | 4.806 | 0.041 | 2.098 | 1.082 | 4.069 |
Number of collected cells | -0.612 | 0.296 | 4.275 | 0.047 | 0.542 | 0.304 | 0.969 |
Serum TSH | 0.285 | 0.217 | 1.725 | 0.216 | 1.330 | 0.869 | 2.035 |
Serum Tg | -0.442 | 0.186 | 5.647 | 0.025 | 1.556 | 1.081 | 2.240 |
Characteristics of ultrasonic signs | 0.804 | 0.358 | 5.044 | 0.037 | 2.234 | 1.108 | 4.507 |
Constant term | 1.309 | 0.684 | 3.662 | 0.091 | 3.702 | 0.969 | 14.149 |
- Citation: Zhang LY, Chen Y, Ao YZ. Value of thyroglobulin combined with ultrasound-guided fine-needle aspiration cytology for diagnosis of lymph node metastasis of thyroid carcinoma. World J Clin Cases 2022; 10(2): 492-501
- URL: https://www.wjgnet.com/2307-8960/full/v10/i2/492.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v10.i2.492