Inflammation-related indicators to distinguish between gastric stromal tumors and leiomyomas: A retrospective study

doi:10.12998/wjcc.v10.i2.458

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Jan 14, 2022 (publication date) through Sep 8, 2024

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World Journal of Clinical Cases

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Clin Cases. Jan 14, 2022; 10(2): 458-468
Published online Jan 14, 2022. doi: 10.12998/wjcc.v10.i2.458

Table 1 Baseline characteristics of patients in gastrointestinal stromal tumors group and gastric leiomyoma group

Characteristics	GIST group (n = 88), (%)		Gastric leiomyoma group (n = 56), (%)		P value
Gender (male/female)	47/41	53.4/46.6	18/38	32.1/67.9	0.012^a
Age (median)	61.1		50.1		0.00^a
ECOG					0.31
0	86	97.7	52	92.8
1	1	1.1	3	5.3
2	1	1.1	1	1.7
Tumor location					0.00^a
Cardia	3	3.4	25	44.6
Fundus	46	52.2	20	35.7
Body	27	30.7	8	14.3
Antrum	12	13.6	3	5.3
Diameter					0.122
≤ 2 cm	11	12.5	14	25
2-5 cm	54	61.4	32	57.1
≥ 5 cm	23	26.1	10	17.9

^aP < 0.05.

GIST: Gastrointestinal stromal tumors; ECOG: Eastern Cooperative Oncology Group.

Table 2 Inflammation indicators of the two groups

	GIST (n = 88)	Gastric leiomyoma (n = 56)	t value	P value
PLR	158.2 ± 8.7	134.3 ± 6.2	2.217	0.028^a
NLR	2.35 ± 0.17	1.68 ± 0.08	3.617	0.00^a
LMR	5.76 ± 0.56	10.82 ± 1.62	2.956	0.004^a
SII	546.2 ± 49.3	384.3 ± 22.1	2.993	0.003^a

^aP < 0.05.

GIST: Gastrointestinal stromal tumors; PLR: Platelet-lymphocyte ratio; NLR: Neutrophil-lymphocyte ratio; LMR: lLymphocyte mononuclear cell ratio.

Table 3 Logistic regression analysis results

	Group	β	SE	Wald	P value	OR	95%CI
Gender	Male	-	-	-	-	1	-
Gender	Female	1.548	0.548	7.97	0.005	4.7	1.605-13.762
Age		-0.097	0.024	16.939	0	0.907	0.866-0.950
Tumor locations	Cardia	-	-	-	-	1	-
	Fundus	-3.501	0.804	18.948	0	0.03	0.006-0.146
	Body	-3.572	0.854	17.482	0.001	0.028	0.005-0.150
	Antrum	-3.315	1.039	10.19	0.001	0.036	0.005-0.278
LMR		0.092	0.042	4.715	0.03	1.096	1.009-1.191

LMR: lLymphocyte mononuclear cell ratio.

Table 4 Subgroup analysis of low-risk gastrointestinal stromal tumors and gastric leiomyoma

	Low-risk GIST (n = 56)	Gastric leiomyoma (n = 56)	t value	P value
PLR	146.1 ± 9.9	134.3 ± 6.2	0.992	0.324
NLR	2.17 ± 0.17	1.68 ± 0.08	2.451	0.016^a
LMR	5.42 ± 0.32	10.82 ± 1.62	3.267	0.002^a
SII	484.5 ± 56.1	384.3 ± 22.1	1.661	0.101

^aP < 0.05.

GIST: Gastrointestinal stromal tumors; PLR: Platelet-lymphocyte ratio; NLR: Neutrophil-lymphocyte ratio; LMR: lLymphocyte mononuclear cell ratio.

Citation: Zhai YH, Zheng Z, Deng W, Yin J, Bai ZG, Liu XY, Zhang J, Zhang ZT. Inflammation-related indicators to distinguish between gastric stromal tumors and leiomyomas: A retrospective study. World J Clin Cases 2022; 10(2): 458-468
URL: https://www.wjgnet.com/2307-8960/full/v10/i2/458.htm
DOI: https://dx.doi.org/10.12998/wjcc.v10.i2.458