Systematic review of Yougui pills combined with levothyroxine sodium in the treatment of hypothyroidism

Table 1 Search strategies in PubMed

ID	Query
#1	“you gui wan” [MESH]
#2	(“you gui wan” [ Title/Abstract]) OR (you-gui-wan [Title/Abstract]) OR (ygw herbal preparation [Title/Abstract]) OR (yougui pill [Title/Abstract])
#3	#1 OR #2
#4	“hypothyroidism”[MESH]
#5	(((((((hypothyroidism [Title/Abstract]) OR (hypothyroidisms [Title/Abstract])) OR (thyroid-stimulating hormone deficiency [Title/Abstract])) OR (thyroid-stimulating, hormone deficiencies [Title/Abstract])) OR (thyroid stimulating hormone deficiency [Title/Abstract])) OR (thyroid-stimulating hormone deficiencies [Title/Abstract])) OR (tsh deficiency [Title/Abstract])) OR (tsh deficiencies [Title/Abstract])
#6	#4 OR #5
#7	#3 AND #6

Table 2 Basic characteristics table

Ref.	Intervention measure	Control measure	Average age (yr)		Duration of treatment/follow-up (wk)
			Experimental group	Control group
Zhang et al[15], 2008	Yougui pills + levothyroxine sodium	Levothyroxine sodium	53	55	8
Li et al[16], 2012	Yougui pills + levothyroxine sodium	Levothyroxine sodium	68.1 ± 5.3	66.7 ± 5.1	12
Zhang et al[17], 2015	Yougui pills + levothyroxine sodium	Levothyroxine sodium	42.7 ± 3.6	42.7 ± 3.6
Li et al[18], 2016	Yougui pills + levothyroxine sodium	Levothyroxine sodium	40.2 ± 9.4	40.2 ± 9.4
Wang et al[19], 2016	Yougui pills + levothyroxine sodium	Levothyroxine sodium	40.12 ± 9.50	40.57 ± 9.53	12
Jiang et al[20], 2017	Yougui pills + levothyroxine sodium	Levothyroxine sodium	40.9 ± 5.6	40.8 ± 5.8	12
Liu et al[21], 2017	Yougui pills + levothyroxine sodium	Levothyroxine sodium	37.98 ± 13.83	38.88 ± 12.10	8
Chen et al[22], 2018	Yougui pills + levothyroxine sodium	Levothyroxine sodium	40.88 ± 5.12	40.95 ± 5.62	12
Shi et al[23], 2018	Yougui pills + levothyroxine sodium	Levothyroxine sodium	44.6 ± 12.4	45.1 ± 11.9	12

Table 3 Methodological quality evaluation of included literature

Ref.	Randomization method	Blind method	Concealment	Integrity of result data	Selective reporting of results	Other bias
Zhang et al[15], 2008	Just mentioned random	Not mentioned	Unclear	Complete data	Low risk	Unclear
Li et al[16], 2012	Random number table	Not mentioned	Unclear	Complete data	Low risk	Unclear
Zhang et al[17], 2015	Not mentioned	Not mentioned	Unclear	Complete data	Low risk	Unclear
Li et al[18], 2016	Just mentioned random	Not mentioned	Unclear	Complete data	Low risk	Unclear
Wang et al[19], 2016	Just mentioned random	Not mentioned	Unclear	Complete data	Low risk	Unclear
Jiang et al[20], 2017	Random number table	Double blind	Unclear	Complete data	Low risk	Unclear
Liu et al[21], 2017	Not mentioned	Not mentioned	Unclear	Complete data	Low risk	Unclear
Chen et al[22], 2018	Not mentioned	Double blind	Unclear	Complete data	Unclear	Unclear
Shi et al[23], 2018	Random number table	Not mentioned	Unclear	Complete data	Unclear	Unclear