Clinical evaluation of prone position ventilation in the treatment of acute respiratory distress syndrome induced by sepsis

Table 1 Comparison of general data of patients between the two groups, n (%)

Group	Sex		Age (yr)	Acute physiological and chronic health score (score)	Sequential organ failure score (score)	Number of basic illnesses
	Female	Male				1 type	2 type	3 type	4 type	5 type	6 type
Conventional treatment group (n = 55)	15 (27.27)	40 (72.73)	53.82 ± 16.08	27.71 ± 4.55	11.76 ± 3.15	5 (9.09)	11 (20.00)	17 (30.91)	14 (25.45)	5 (9.09)	3 (5.45)
Prone position ventilation treatment group (n = 47)	14 (29.79)	33 (70.21)	53.15 ± 14.16	28.28 ± 4.49	10.57 ± 3.01	5 (10.64)	14 (29.79)	19 (40.43)	4 (8.5)	4 (8.51)	1 (2.13)
χ2 /t value	0.079		0.222	0.634	1.941	6.551
P value	0.779		0.825	0.527	0.055	0.256

Table 2 Differences in respiratory mechanics indices of patients in each group before and after ventilation

Group	Oxygenation index				Cst (mL/cmH2O)				Pplat (cmH2O)
	Day 1	Day 2	Day 4	Day 7	Day 1	Day 2	Day 4	Day 7	Day 1	Day 2	Day 4	Day 7
Routine treatment group (n = 55)	85.31 ± 25.69	198.33 ± 42.81	254.86 ± 49.56	308.03 ± 57.47	24.09 ± 2.87	36.06 ± 3.62	36.38 ± 3.75	36.45 ± 3.82	25.32 ± 1.06	21.96 ± 0.79	21.80 ± 0.72	21.73 ± 0.65
Prone position ventilation treatment group (n = 47)	129.34 ± 40.02	205.23 ± 41.81	255.50 ± 54.54	320.81 ± 66.15	29.80 ± 3.52	36.24 ± 3.65	36.42 ± 3.72	36.55 ± 3.90	22.01 ± 0.82	21.90 ± 0.75	21.76 ± 0.68	21.70 ± 0.61
t value	6.704	0.820	0.062	1.044	9.024	0.249	0.054	0.131	17.410	0.391	0.287	0.239
P value	0.001	0.414	0.951	0.299	0.001	0.804	0.957	0.896	0.001	0.696	0.775	0.812

Cst: Lung compliance; Pplat: Platform pressure.

Table 3 Differences in hemodynamic indices of patients in each group on the first day after ventilation

Group	HR (time/min)	MAP (mmHg)	CVP (cmH2O)	LVEF (%)
Conventional treatment group (n = 55)	95.60 ± 10.31	89.11 ± 5.67	8.87 ± 1.92	44.32 ± 1.35
Prone position ventilation treatment group (n = 47)	97.82 ± 12.51	90.50 ± 5.72	9.17 ± 2.32	44.30 ± 1.30
t value	0.983	1.229	0.715	0.076
P value	0.328	0.222	0.477	0.940

HR: Heart rate; MAP: mean arterial pressure; CVP: Central venous pressure; LVEF: Left ventricular ejection fraction.

Table 4 Differences in mechanical ventilation time and intensive care unit stay in patients in each group (d)

Group	Mechanical ventilation time	ICU hospitalization
Conventional treatment group (n = 55)	24.38 ± 7.95	30.02 ± 9.75
Prone position ventilation treatment group (n = 47)	23.88 ± 7.02	28.45 ± 8.23
t value	0.334	0.870
P value	0.739	0.386

ICU: Intensive care unit.

Table 5 Differences in inflammatory factors (ug/L) in patients of each group before and after ventilation

Group	CRP (mg/L)	PCT (ug/L)	IL-6 (ug/L)
Conventional treatment group (n = 55)	12.92 ± 1.06	20.85 ± 2.21	76.29 ± 3.75
Prone position ventilation treatment group (n = 47)	12.80 ± 1.01	20.80 ± 2.25	76.25 ± 2.26
t value	0.582	0.113	0.064
P value	0.562	0.910	0.949

CRP: C-reactive protein; PCT: Procalcitonin; IL-6: Interleukin-6.

Table 6 Difference in death rate on day 28 and day 90 for patients in each group, n (%)

Group	Day 28 mortality	Day 90 mortality
Conventional treatment group (n = 55)	16 (29.09)	25 (45.45)
Prone position ventilation treatment group (n = 47)	6 (12.77)	12 (25.53)
χ2 value	3.993	4.352
P value	0.046	0.037