Value of neutrophil-lymphocyte ratio in evaluating response to percutaneous catheter drainage in patients with acute pancreatitis

Table 1 Baseline demographic details and outcome parameters

Characteristic	Overall cohort
Age, yr (mean ± SD)	40 ± 13.6
Sex (%)
Males	64.5
Females	35.5
Etiology, n (%)
Alcohol	79 (51)
Gallstones	63 (40.6)
ERCP	6 (3.9)
Idiopathic	5 (3.2)
Hyperparathyroidism	2 (1.3)
Co-morbidities, n (%)	32
Diabetes mellitus	19 (59.4)
Hypertension	21 (65.6)
Coronary artery disease	8 (25)
Chronic obstructive airway disease	14 (43.7)
Obesity, n (%)	18 (11.6%)
Severity, n (%)
Moderately severe	72 (46.4)
Severe	83 (53.5)
Pain to PCD interval, d (median)	24
Site of collection, n (%)
Lesser sac	94 (62.6)
Paracolic gutter	28 (18.7)
Lesser sac and paracolic gutter	16 (10.7)
Perisplenic	4 (2.7)
Perihepatic	3 (2)
Pelvic	5 (3.3)
Infected necrosis, n (%)	75 (36.7)
Organ failure, n (%)	100 (64.5)
Length of hospital stay, d (mean ± SD)	22 ± 19.3
Length of ICU stay, d (mean ± SD)	6.1 ± 10.1
Surgery, n (%)	24 (15.4)
Endoscopic drainage, n (%)	7 (4.5)
Mortality, n (%)	32 (20.6)

ERCP: Endoscopic retrograde cholangiopancreatography; PCD: Percutaneous catheter drainage; ICU: Intensive care unit.

Table 2 Group statistics

Parameters		Overall cohort (n = 155)
Characteristics	Compared variable	Group I	Group II	P value
	Number	109	46
Pain to PCD interval	Mean	39.8	54.1	0.249
Site of collection (%)	Lesser sac	64.2	52.2	0.464
	Paracolic	16.5	21.7
	Lesser sac + paracolic	11	8.7
Procalcitonin	Mean	3.2	5.4	0.331
Collection size	Mean	11.4	11.5	0.974
Catheter size	< 12F	23	8	0.598
	> 12F	86	38
RAC severity	Moderately severe	62	11	< 0.001
	Severe	47	35
Infected necrosis	No	71	27	0.447
	Yes	38	19
Organ failure	No	43	11	0.076
	Yes	66	34

PCD: Percutaneous catheter drainage; RAC: Revised Atlanta classification.

Table 3 Serial white blood cell count and neutrophil-lymphocyte ratio

Day	n	Median	IQR (25%-75%)
WBC
0	155	14.9	9.9-20.7
1	110	12.3	8.9-17.4
2	151	11.6	8.3-17.6
3	102	12.4	8.9-16.2
NLR
0	140	8.2	5.2-14.1
1	88	7.2	4.4-12
2	136	6.4	4.1-11.9
3	89	6.6	3.8-12.1

0: Prior to percutaneous catheter drainage (PCD); 1: 24 h ollowing PCD; 2: 48 h following PCD; 3: 72 h following PCD; WBC: White blood cell count; NLR: Neutrophil-lymphocyte ratio.

Table 4 Area under the curve for serial white blood cell count and neutrophil-lymphocyte ratio for differentiating responders from non-responders to percutaneous catheter drainage

Time point	WBC	NLR
Baseline (0)	0.508	0.401
24 h (1)	0.602	0.682
48 h (2)	0.468	0.407
72 h (3)	0.416	0.427

WBC: White blood cell count; NLR: Neutrophil-lymphocyte ratio.