Published online Jun 6, 2020. doi: 10.12998/wjcc.v8.i11.2173
Peer-review started: December 27, 2019
First decision: February 18, 2020
Revised: March 27, 2020
Accepted: May 13, 2020
Article in press: May 13, 2020
Published online: June 6, 2020
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The Helicobacter pylori (H. pylori) infection rate in China is approximately 50%. H. pylori is a pathogenic factor of peptic ulcer and chronic gastritis. In addition, H. pylori infection may also be associated with a variety of cardiovascular diseases in elderly people, such as arteriosclerosis, coronary heart disease, and cerebral infarction, having deleterious effect on their health. With the aging of the population, the disease characteristics of the elderly population have been increasingly valued by the whole society. We conducted an epidemiological survey of H. pylori infection among elderly people in Beijing to provide a basis for health management of H. pylori infection.
To understand the epidemiological characteristics of H. pylori infection in elderly people in Beijing.
A total of 1090 elderly people aged more than 60 years from different parts of Beijing (urban and rural areas) were selected using the random cluster sampling method. Structured questionnaires were completed during home visits and the 13C-urea breath test was conducted for H. pylori detection.
The prevalence of H. pylori infection was 46.5% (507/1090). The infection rate in men was 51.8%, which was significantly higher than that in women (42.5%; P < 0.05). The H. pylori infection rate in illiterate people was significantly higher than that in literate persons (53.5% vs 44.8%, P < 0.05). The total infection rate of H. pylori gradually increased with age and the difference was statistically significant (P < 0.01). The H. pylori infection rate in smokers was significantly higher than that in non-smokers and those who had quit smoking (P < 0.05).
The prevalence of H. pylori infection among elderly people is 46.5% and the infection rate gradually increases with age. Sex, education level, age, and smoking were determined to be H. pylori infection risk factors. The relationship of H. pylori infection with region, occupation, drinking, and diet structure needs to be further studied.
Core tip:Helicobacter pylori (H. pylori) infection is globally distributed and elderly people are a high-risk population. With the ageing of society, the elderly population suffering from digestive diseases combined with H. pylori infection has accounted for a considerable proportion. We conducted an epidemiological survey of H. pylori infection among elderly people in Beijing to provide a basis for health management of H. pylori infection. This is a large elderly population and interesting associations between H. pylori and subjects’ habits have been found. This article is the latest epidemiological study on the H. pylori infection in elderly people in Beijing, China.
- Citation: Zhu HM, Li BY, Tang Z, She J, Liang XY, Dong LK, Zhang M. Epidemiological investigation of Helicobacter pylori infection in elderly people in Beijing. World J Clin Cases 2020; 8(11): 2173-2180
- URL: https://www.wjgnet.com/2307-8960/full/v8/i11/2173.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v8.i11.2173
Helicobacter pylori (H. pylori) infection is globally distributed[1] and elderly people are a high-risk population. An Italian study reported that the infection rate among asymptomatic elderly people reaches 40%-60%, while the infection rate in the elderly with gastrointestinal diseases is > 70%[2]. H. pylori can be infected in early childhood, although most infected people have no symptoms in their lifetime, and approximately 1%[3] develop gastric cancer or gastric mucosa-associated lymphoid tissue lymphoma. Due to its ability to trigger gastric mucosal carcinogenesis, the International Agency for Research on Cancer has defined H. pylori as a class I carcinogen as early as 1994[4]. H. pylori is a pathogenic factor of peptic ulcer and chronic gastritis. In addition, H. pylori infection may also be associated with a variety of cardiovascular diseases in elderly people, such as arteriosclerosis, coronary heart disease, and cerebral infarction[5,6], having deleterious effect on their health. H. pylori infection is related to age, socioeconomic status, education level, and other factors. The infection rate in China is approximately 50%[7]. With the aging of the population, the disease characteristics of the elderly population have been increasingly valued by the whole society. We conducted an epidemiological survey of H. pylori infection among elderly people in Beijing to provide a basis for health management of H. pylori infection.
The cluster sampling was based on a random sample of the elderly population in both urban (Xuanwu) and rural (Daxing and Huairou) areas in Beijing, stratified by living conditions, education, and age in 2017. Informed consent was obtained from all the examinees. This study was reviewed and approved by the Xuanwu Hospital Institution Review Board.
Sample size estimation: According to the literature, the infection rate of H. pylori in the elderly is 40%[2]. In order to understand the infection rate of H. pylori in the target population, the error is required to be no more than 2% (α = 0.05), and the sample size is 1180. A total of 1180 questionnaires were distributed and 1090 were recovered, with a response rate of 92.3%.
Eligibility criteria: The inclusion criteria were: (1) Age over 60 years old (gender unlimited); and (2) No antibiotics, bismuth, or proton pump inhibitors have been taken within 1 mo. The exclusion criteria were: (1) Those who did not have an empty stomach for more than 4 h on the test day; (2) Those who could not cooperate with the examination; (3) Those who underwent partial gastrectomy; and (4) Those who were allergic to urea-13C.
A questionnaire survey was carried out by the uniformly trained professionals. The survived data included history of H. pylori infection, dietary and hygiene habits, and smoking and drinking history. In addition, physical examination was performed, including blood pressure, height, weight, and waist and hip circumference measurement. Samples for blood biochemistry were also collected.
The 13C urea breath test (13C-UBT) was used for detection of H. pylori infection. The test was performed on an empty stomach in the morning using a commercial kit (Beijing Haide Run Pharmaceutical Group Co., Ltd.). First, baseline samples were collected. Subjects were instructed to exhale as much air as possible in the blue bottom air bag. Next, they took urea 13C tablets with 100 mL of warm water. After 30 min, testing samples were collected. Subjects were instructed to exhale as much air as possible in the red bottom air bag. The 0-min and 30-min sample air bags were analyzed using external 13C infrared spectrometer for 13CO2 detection (IRIS-Lab 13C infrared spectrometer; Wagner, Germany). The detection value (DOB) was determined as follows: DOB = δ‰(30 min) - δ‰(0 min). The test was considered positive when DOB ≥ 4.0.
The survey data were analyzed using EpiData software. After comparing and correcting the errors, the EpiData data were exported and converted into SPSS files. Measurement data are expressed as the mean ± SD (χ ± s) and were analyzed using the t test. Count data are expressed as rates (%) and were analyzed using the χ2 test. P < 0.05 was considered statistically significant. All calculations were performed using SPSS ver. 17.0 statistical software.
A total of 1180 elderly people aged > 60 years were randomly selected. Among them, 1090 were tested for H. pylori. Their average age was 70.77 years. There were 469 (43.0%) men and 621 (56.9%) women, with 665 (61.0%) and 425 (39.0%) subjects from rural and urban areas, respectively. According to the age group, there were 279 (25.5%) subjects aged 60-64 years; 263 (24.1%) aged 65-69 years; 209 (19.2%) aged 70-74 years; 171 (15.6%) aged 75-80 years; and 168 (15.4%) aged 80 years or older.
Of the 1090 elderly persons, 507 were found to have H. pylori infection, with an infection rate of 46.5%. According to the sex, the infection rate was significantly higher in men (51.8%) than in women (42.5%) (χ2 = 9.290, P < 0.05). According to the education level, the H. pylori infection rate was significantly higher in illiterate (53.5%) than in literate (44.8%) subjects (χ2 = 5.124, P < 0.05). According to the region of residence, the urban infection rate (48.9%) was slightly higher than that of rural areas (44.9%), but there was no significant difference between the two groups (χ2 = 1.650, P > 0.05, Table 1).
The H. pylori infection rates in different age groups are presented in Table 2. The total infection rate gradually increased with age and the difference was statistically significant (χ2 = 13.518, P = 0.009).
Among the 1090 elderly subjects surveyed, 1081 had clearly defined occupational categories. The positive rate of H. pylori infection was highest among those who had performed light physical work. However, there was no significant difference among different groups (χ2 = 1.576, P > 0.05; Table 3).
| Occupational | Subjects (n) | H. pylori positive (n) | H. pylori infection rate (%) | P value |
| Mainly brain work | 169 | 75 | 44.3 | 0.455 |
| Light physical work | 259 | 129 | 49.8 | |
| Heavy physical work | 653 | 299 | 45.7 | |
| Total | 1081 | 503 |
Among the 1090 elderly subjects, we could clearly define the diet structure for 1077. According to the questionnaire, in the non-staple food, meatarians were defined as eating meat more than 3 days a week, and mainly vegetarians were defined as eating vegetables every day and meat occasionally. And the above situation needs to last for 1-5 years.
The H. pylori infection rate was the highest (47.5%) among the elderly subjects with a balanced diet. However, there was no significant difference among the three groups (χ2 = 0.393, P > 0.05; Table 4).
| Dietary structure | Subjects (n) | H. pylori positive(n) | H. pylori infection rate (%) | P value |
| Mainly vegetarian | 488 | 223 | 45.6 | 0.821 |
| Mainly meat | 84 | 38 | 45.2 | |
| Balanced diet | 505 | 240 | 47.5 | |
| Total | 1077 | 501 |
According to the World Health Organization's relevant standards for defining drinkers and smokers, people who smoke continuously or cumulatively for half a year or more are defined as smokers; people who drink at least twice in seven days or for more than one year are defined as drinkers. Among the 1090 elderly subjects surveyed, the alcohol consumption status was clearly defined for 1076. The positive rate of H. pylori infection was the highest among those consuming alcohol (51.0%); however, the difference among the groups was not statistically significant (χ2 = 3.832, P > 0.05).
The smoking status was defined for 1081 of the 1090 elderly subjects surveyed. The positive rate of H. pylori infection in smokers was significantly higher than that in non-smokers and those who had quit smoking (χ2 = 6.821, P < 0.05; Table 5).
| Subjects (n) | H. pylori positive(n) | H. pylori infection rate (%) | P value | |
| Consuming alcohol | 0.147 | |||
| Not drinking | 738 | 330 | 44.7 | |
| Drinking | 292 | 149 | 51.0 | |
| Quitting drinking | 46 | 19 | 41.3 | |
| Total | 1076 | 498 | ||
| Smoking | 0.033 | |||
| Not smoking | 767 | 346 | 45.1a | |
| Smoking | 210 | 114 | 54.2 | |
| Quitting smoking | 104 | 43 | 41.3 | |
| Total | 1081 | 503 |
The results of this study showed that the current infection rate of H. pylori in this population in Beijing was 46.5%. According to epidemiological surveys, the infection rate of H. pylori was 39.9%-84.2% worldwide[8-11]. The infection rate varies greatly in different countries and regions. Older people over 60 years of age are still the group with a higher infection rate[2]. In 2005, the infection rates of H. pylori among elderly people in Shanghai and Beijing reached 72.4% and 83.4%, respectively[12,13]. The reasons for the decrease in this rate in Beijing are thought to be as follows: (1) The data is the latest statistical data from the past three years, allowing for greater differences when compared with older data; and (2) In previous epidemiological studies, H. pylori serum antibody test was used. The disadvantage of serological test is that it cannot distinguish the present or previous infection of H. pylori. Compared with previous serological tests, the 13C-UBT used in this study has the advantage of high sensitivity and specificity for detecting a current H. pylori infection[14,15]. The results of the 13C-UBT are related to the amount of bacteria in the stomach, the site of colonization in the stomach, and gastrointestinal motility, and may be affected by other diseases, although it can better reflect the status of H. pylori infection. According to the data, H. pylori infection rates in most countries have been declining since the beginning of the 21st century[16-18]. A multicenter longitudinal study in South Korea showed that the positive rate of serological detection of H. pylori infection in 2011 was 54.4% (5873/10796), which was significantly lower than 59.6% in 2005 and 66.9% in 1998. The declining trend of serological positive rate of H. pylori infection may be due to the birth cohort effect. This suggests that we need to further study the human host factors and socio-economic and health factors associated with H. pylori infection[19].
A wealth of epidemiological data[20,21] indicates that the prevalence of H. pylori infection in men is higher than that in women. This study showed that the prevalence of H. pylori in elderly men in Beijing was higher than that in women (P < 0.05), which was consistent with the results of foreign surveys. The reason may be that the difference in hormone secretion between men and women affects gastric emptying and bacterial load, which requires further study. More social activities for men increase the chance of H. pylori infection. The living habits and eating habits of men and women are different, which can also increase the chance of H. pylori infection[22].
Many epidemiological studies have shown that the prevalence of H. pylori increases with age[23,24]. Our survey showed that the total infection rate of H. pylori in the elderly population is gradually increasing with age, and the difference was statistically significant (P < 0.05). It has also been recognized that H. pylori infection is closely related to the educational level. Studies have shown that individuals with lower educational level and socioeconomic status were 5.5 and 6.6 times more likely to be infected with H. pylori, respectively[25]. This survey showed that the infection rate of H. pylori among illiterate elderly people was significantly higher than that in literate people (P < 0.05), which was consistent with the survey results at home and abroad.
H. pylori infection is usually closely related to people's living habits. This study showed that the infection rates in the elderly people had no significant correlation with different occupations and different dietary structures. Previous surveys[13] of elderly persons in different urban and rural areas of Beijing (Huairou, Daxing, and Xuanwu) showed that the total infection rate of H. pylori in mountainous areas was higher than that in urban and suburban areas, with significantly statistical differences. However, in our survey, there was no significant difference in the H. pylori infection rate between urban and rural areas in Beijing (P > 0.05), which may be related to the acceleration of urbanization in Beijing, the large population mobility, the urban and rural environmental health, and the reduction of differences in socio-economic conditions.
The positive rate of H. pylori infection was the highest among those consuming alcohol. The H. pylori infection rate in smokers was significantly higher than that in non-smokers. It is suggested that tobacco and alcohol could damage the defense barrier of the gastric mucosa, affect prostaglandin synthesis in the gastric mucosa, and reduce mucus secretion and mucosal blood flow, resulting in weakening of the defense function of the gastric mucosa and making it vulnerable to H. pylori invasion[26-28]. A meta-analysis also showed that the infection rate of H. pylori in drinkers has decreased and that moderate drinking may help to eliminate H. pylori[29].
The inadequacy of this study is that the selected elderly population has certain particularity. Chronic atrophic gastritis has a high incidence in the elderly and increases with age[26]. The accuracy of H. pylori diagnosis in atrophic gastritis is low. Because of low acid in the stomach, other urease positive bacteria may be colonized in patients with chronic atrophic gastritis, thus leading to false positive results[30].
In conclusion, H. pylori infection among the elderly people in Beijing is closely related to sex, age, smoking, and education level, while the relationship of H. pylori infection with region, diet structure, occupation, and drinking needs further study.
Helicobacter pylori (H. pylori) infection is globally distributed. The H. pylori infection rate in China is approximately 50%. A large number of studies show that H. pylori infection rate increases with age. The infection rate among asymptomatic elderly people is 40%-60%, while the rate among elderly people with gastrointestinal diseases is more than 70%. This may be due to the low immunity of the elderly, poor living and health conditions, and low socio-economic status. H. pylori is a pathogenic factor of peptic ulcer and chronic gastritis. Compared with young people, the detection and treatment of H. pylori in the elderly should be regarded as an important goal in clinical practice, because it plays an important role in gastrointestinal diseases in the elderly. With the aging of the population, the disease characteristics of the elderly population have been increasingly valued by the whole society. We conducted an epidemiological survey of H. pylori infection among elderly people in Beijing to provide a basis for health management of H. pylori infection.
With the increase of age, the infection rate of H. pylori also increases. Compared with young people, the elderly have more non-steroidal anti-inflammatory drug-related gastrointestinal damage and higher incidence of functional dyspepsia, chronic atrophic gastritis, and gastric cancer. H. pylori infection will not only aggravate the non-steroidal anti-inflammatory drug-related gastrointestinal damage, but is also the known cause of chronic atrophic gastritis and gastric cancer. H. pylori infection may also be associated with a variety of cardiovascular diseases in elderly people, such as arteriosclerosis, coronary heart disease, and cerebral infarction, having deleterious effect on their health. Therefore, H. pylori infection is more harmful to the elderly. We conducted an epidemiological survey of H. pylori infection among elderly people in Beijing to further improve the knowledge, prevention, diagnosis, and treatment of H. pylori infection and related diseases in the elderly.
The main objective of this study was to investigate the status of H. pylori infection in the elderly in different areas of Beijing. At the same time, we investigated the influencing factors of H. pylori infection in the elderly, including gender, region, occupation, history of H. pylori infection, and dietary and hygiene habits, to provide a basis for health management of H. pylori infection.
The 3C urea breath test (13C-UBT) was used for detection of H. pylori infection. The test was performed on an empty stomach in the morning using a commercial kit. First, baseline samples were collected. Subjects were instructed to exhale as much air as possible in the blue bottom air bag. Next, they took urea 13C tablets with 100 mL of warm water. After 30 min, testing samples were collected. Subjects were instructed to exhale as much air as possible in the red bottom air bag. The 0-min and 30-min sample air bags were analyzed using external 13C infrared spectrometer for 13CO2 detection. Compared with serological tests, the 13C-UBT used in this study has the advantage of high sensitivity and specificity for detecting a current H. pylori infection.
The prevalence of H. pylori in elderly men in Beijing was higher than that in women (P < 0.05). Moreover, the infection rate of H. pylori among illiterate elderly people was significantly higher than that in literate people (P < 0.05). However, the infection rates in the elderly people had no significant correlation with occupation or dietary structure. In addition, the positive rate of H. pylori infection was the highest among those consuming alcohol and the H. pylori infection rate in smokers was significantly higher than that in non-smokers.
H. pylori infection among the elderly people in Beijing is closely related to sex, age, smoking, and education level.
The relationship of H. pylori infection with region, diet structure, occupation, and drinking needs further study.
Manuscript source: Unsolicited manuscript
Specialty type: Medicine, research and experimental
Country/Territory of origin: China
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| 1. | Peleteiro B, Bastos A, Ferro A, Lunet N. Prevalence of helicobacter pylori infection worldwide: A systematic review of studies with national coverage. Dig Dis Sci. 2014;59:1698-1709. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 199] [Cited by in F6Publishing: 223] [Article Influence: 22.3] [Reference Citation Analysis (6)] |
| 2. | Pilotto A, Franceschi M. Helicobacter pylori infection in older people. World J Gastroenterol. 2014;20:6364-6373. [PubMed] [DOI] [Cited in This Article: ] [Cited by in CrossRef: 50] [Cited by in F6Publishing: 38] [Article Influence: 3.8] [Reference Citation Analysis (3)] |
| 3. | Sugano K. Screening of gastric cancer in Asi. Best Pract Res Clin Gastroenterol. 2015;29:895-905. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 128] [Cited by in F6Publishing: 144] [Article Influence: 16.0] [Reference Citation Analysis (0)] |
| 4. | Schistosomes, liver flukes and helicobacter pylori. IARC working group on the evaluation of carcinogenic risks to humans. Lyon, 7-14 June 1994. IARC Monogr Eval Carcinog Risks Hum. 1994;61:1-241. [PubMed] [Cited in This Article: ] |
| 5. | Khademi F, Vaez H, Momtazi-Borojeni AA, Majnooni A, Banach M, Sahebkar A. Bacterial infections are associated with cardiovascular disease in Iran: a meta-analysis. Arch Med Sci. 2019;15:902–911. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 11] [Cited by in F6Publishing: 12] [Article Influence: 2.4] [Reference Citation Analysis (0)] |
| 6. | Choi JM, Lim SH, Han YM, Lee HS, Seo JY, Park HE, Kwak MS, Chung GE, Choi SY, Kim JS. Association between helicobacter pylori infection and arterial stiffness: Results from a large cross-sectional study. PLoS One. 2019;14:e0221643. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 15] [Cited by in F6Publishing: 20] [Article Influence: 4.0] [Reference Citation Analysis (0)] |
| 7. | Liu WZ, Xie Y, Lu H, Cheng H, Zeng ZR, Zhou LY, Chen Y, Wang JB, Du YQ, Lu NH. Helicobacter pylori and peptic ulcer blood group/National Helicobacter pylori research collaboration group. Fifth National Consensus Report on helicobacter pylori infection management. Zhonghua Xiaohua Zazhi. 2017;37:364-378. [DOI] [Cited in This Article: ] |
| 8. | Ueda J, Gosho M, Inui Y, Matsuda T, Sakakibara M, Mabe K, Nakajima S, Shimoyama T, Yasuda M, Kawai T, Murakami K, Kamada T, Mizuno M, Kikuchi S, Lin Y, Kato M. Prevalence of helicobacter pylori infection by birth year and geographic area in Japan. Helicobacter. 2014;19:105–110. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 68] [Cited by in F6Publishing: 69] [Article Influence: 6.9] [Reference Citation Analysis (0)] |
| 9. | Sivapalasingam S, Rajasingham A, Macy JT, Friedman CR, Hoekstra RM, Ayers T, Gold B, Quick RE. Recurrence of helicobacter pylori infection in Bolivian children and adults after a population based “screen and treat” strategy. Helicobacter. 2014;19:343-348. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 25] [Cited by in F6Publishing: 24] [Article Influence: 2.4] [Reference Citation Analysis (0)] |
| 10. | Laszewicz W, Iwanczak F, Iwanczak B. Seroprevalence of helicobacter pylori infection in Polish children and adults depending on socioeconomic status and living conditions. Adv Med Sci. 2014;59:147–150. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 40] [Cited by in F6Publishing: 51] [Article Influence: 5.1] [Reference Citation Analysis (0)] |
| 11. | Zhang M, Zhou YZ, Li XY, Tang Z, Zhu HM, Yang Y, Chhetri JK. Seroepidemiology of helicobacter pylori infection in elderly people in the Beijing region, China. World J Gastroenterol. 2014;20:3635–3639. [PubMed] [DOI] [Cited in This Article: ] [Cited by in CrossRef: 19] [Cited by in F6Publishing: 16] [Article Influence: 1.6] [Reference Citation Analysis (0)] |
| 12. | Chen SY, Liu TS, Fan XM, Dong L, Fang GT, Tu CT, Gu XY, Wang JY. [Survey of helicobacter pylori infection and its risk factors in Shanghai]. Chin Med J (Engl). 2005;85:802-806. [PubMed] [DOI] [Cited in This Article: ] [Cited by in F6Publishing: 1] [Reference Citation Analysis (0)] |
| 13. | Zhang M, Tang Z, Tang X, Cai L, Zhang H, Sun CS. Seroepidemiological comparison of helicobacter pylori infection among the elderly population in Beijing. Shijie Huaren Xiaohua Zazhi. 2005;13:1978-1980 [10.11569/wcjd.v13.i16.1978]. [Cited in This Article: ] |
| 14. | Tonkic A, Vukovic J, Cindro PV, Pisac VP, Tonkic M. Diagnosis of helicobacter pylori infection: a short review. Wien Klin Wochenschr. 2018;130:530–534. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 11] [Cited by in F6Publishing: 14] [Article Influence: 2.3] [Reference Citation Analysis (0)] |
| 15. | Rahim MAA, Johani FH, Shah SA, Hassan MR, Manaf MRA. 13 C-Urea Breath Test Accuracy for helicobacter pylori Infection in the Asian Population: A Meta-Analysis. Ann Glob Health. 2019;85:110. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 9] [Cited by in F6Publishing: 11] [Article Influence: 2.2] [Reference Citation Analysis (0)] |
| 16. | Burucoa C, Axon A. Epidemiology of helicobacter pylori infection. Helicobacter. 2017;22 Suppl 1. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 98] [Cited by in F6Publishing: 138] [Article Influence: 19.7] [Reference Citation Analysis (0)] |
| 17. | Sonnenberg A, Lash RH, Genta RM. A national study of helicobactor pylori infection in gastric biopsy specimens. Gastroenterology. 2010;139:1894–1901. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 153] [Cited by in F6Publishing: 165] [Article Influence: 11.8] [Reference Citation Analysis (0)] |
| 18. | Morilla AM, Álvarez-Argüelles ME, Duque JM, Armesto E, Villar H, Melón S. Primary antimicrobial resistance rates and prevalence of helicobacter pylori infection in the north of Spain. A 13-year retrospective study. Gastroenterol Hepatol. 2019;42:476-485. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 13] [Cited by in F6Publishing: 13] [Article Influence: 2.6] [Reference Citation Analysis (0)] |
| 19. | Lim SH, Kwon JW, Kim N, Kim GH, Kang JM, Park MJ, Yim JY, Kim HU, Baik GH, Seo GS, Shin JE, Joo YE, Kim JS, Jung HC. Prevalence and risk factors of helicobacter pylori infection in Korea: nationwide multicenter study over 13 years. BMC Gastroenterol. 2013;13:104. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 149] [Cited by in F6Publishing: 157] [Article Influence: 14.3] [Reference Citation Analysis (0)] |
| 20. | Petruzziello C, Sinatti D, Gnarra M, Migneco A, Tesori V, Graziani C, Gasbarrini A, Franceschi F, Ojetti V. May Gender or Ethnicity Affect Delta Over Baseline Values Obtained by 13-C Urea Breath Test? Rev Recent Clin Trials. 2017;12:187-192. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 1] [Cited by in F6Publishing: 2] [Article Influence: 0.3] [Reference Citation Analysis (0)] |
| 21. | Committee on Practice Bulletins-Obstetrics. Practice bulletin No.177: Obstetric analgesia and anesthes. Obstet Gynecol. 2017;129:e73-e89. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 73] [Cited by in F6Publishing: 70] [Article Influence: 10.0] [Reference Citation Analysis (0)] |
| 22. | Ibrahim A, Morais S, Ferro A, Lunet N, Peleteiro B. Sex-differences in the prevalenceof helicobacter pylori infection in pediatric and adult populations: Systematic review and meta-analysis of 244 studies. Dig Liver Dis. 2017;49:742-749. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 59] [Cited by in F6Publishing: 70] [Article Influence: 10.0] [Reference Citation Analysis (1)] |
| 23. | Zhang WD, Hu FL, Xiao SD, Xu ZM. Epidemiological Survey of helicobacter pylori infection in natural population of China. Xiandai Xiaohua Ji Jieru Zhenliao. 2010;15:265-270. [DOI] [Cited in This Article: ] |
| 24. | Curado MP, de Oliveira MM, de Araújo Fagundes M. Prevalence of helicobacter pylori infection in Latin America and the Caribbean populations: A systematic review and meta-analysis. Cancer Epidemiol. 2019;60:141-148. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 17] [Cited by in F6Publishing: 13] [Article Influence: 2.6] [Reference Citation Analysis (0)] |
| 25. | den Hollander WJ, Holster IL, den Hoed CM, van DeurzenF, van Vuuren AJ, Jaddoe VW, Hofman A, Perez Perez GI, Blaser MJ, Moll HA, Kuipers EJ. Ethnicity is a strong predictor for helicobacter pylori infection in young women in a multi-ethnic European city. J Gastroenterol Hepatol. 2013;28:1705-11. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 39] [Cited by in F6Publishing: 42] [Article Influence: 3.8] [Reference Citation Analysis (1)] |
| 26. | Digestive branch of Chinese Medical Association. Consensus on chronic gastritis in China (2017, Shanghai). Zhonghua Xiaohua Zazhi. 2017;37:721-738. [DOI] [Cited in This Article: ] |
| 27. | Tsutsumi S, Mima S, Tomisato W, Hoshino T, Tsuchiya T, Mizushima T. Molecular mechanism of adaptive cytoprotection induced by ethanol in human gastric cells. Exp Biol Med (Maywood). 2003;228:1089-95. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 7] [Cited by in F6Publishing: 9] [Article Influence: 0.4] [Reference Citation Analysis (0)] |
| 28. | Luo XJ, Liu B, Dai Z, Li TB, Li NS, Zhang XJ, Yang ZC, Li YJ, Peng J. Expression of apoptosis-associated microRNAs in ethanol-induced acute gastric mucosal injury via JNK pathway. A1cohol. 2013;47:481-493. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 30] [Cited by in F6Publishing: 28] [Article Influence: 2.5] [Reference Citation Analysis (0)] |
| 29. | Liu SY, Han XC, Sun J, Chen GX, Zhou XY, Zhang GX. Alcohol intake and helicobacter pylori infection: A dose-response meta-analysis of observational studies. Infect Dis (Lond). 2016;48:303-309. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 14] [Cited by in F6Publishing: 17] [Article Influence: 1.9] [Reference Citation Analysis (0)] |
| 30. | Furuta T, Baba S, Yamade M, Uotani T, Kagami T, Suzuki T, Tani S, Hamaya Y, Iwaizumi M, Osawa S, Sugimoto K. High Incidence of Autoimmune Gastritis in Patients Misdiagnosed With Two or More Failures of H. Pylori Eradication. Aliment Pharmacol Ther. 2018;48:370-377. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 29] [Cited by in F6Publishing: 32] [Article Influence: 5.3] [Reference Citation Analysis (0)] |