Impacts of statin and metformin on neuropathy in patients with type 2 diabetes mellitus: Korean Health Insurance data

Figure 1 Schematic of the study plan including the medication exposure period and event (newly developed neuropathy) detection period. Neuropathy was checked as new onset neuropathy that was detected at least 90 d after first exposure to issued medication to reduce detection bias and determine whether new onset neuropathy was affected by these medications. T2DM: Type 2 diabetes mellitus; ICD-10: International Statistical Classification of Diseases and Related Health Problems, 10^th revision; SNRI: Serotonin-norepinephrine reuptake inhibitor.

Figure 2 Flow charts of the step-wise inclusion of participants from the 2016 and 2017 Health Insurance Review and Assessment national patient sample. A: 2016; B: 2017. HIRA: Health Insurance Review and Assessment; NPS: National patient sample; T2DM: Type 2 diabetes mellitus.