Genetic mutations associated with sensitivity to neoadjuvant chemotherapy in metastatic colon cancer: A case report and review of literature

Figure 1 Result of tissue biopsy (× 200, hematoxylin-eosin staining).

Figure 2 Response after the 12-cycle chemotherapy regimen. A: Image on January 11, 2019 (before treatment); B: Image on April 13, 2019 (after the third treatment); C: Image on September 15, 2019 (after the sixth treatment); and D: Image on January 10, 2020 (after the twelfth treatment). Note: The spleen enlarged significantly with treatment (B and C).

Figure 3 Meta-analysis of KRAS mutation rate. A: KRAS; B: TP53; C: SMAD4.