Oral granuloma in a pediatric patient with chronic graft-versus-host disease: A case report

Figure 1 Oral mucositis of the lip and buccal region. There were no findings suggesting lichen planus. A: A pedunculated nodule 8 mm × 5 mm in size and a sessile nodule 2 mm × 2 mm in size in the lower lip mucosa (arrow); B: The left buccal mucosa was grayish-white with a bleeding nodule (arrow).

Figure 2 One month after the first visit, all lesions spontaneously reduced. A and B: Oral nodules in the lower lip mucosa had disappeared 1 mo after the first visit.

Figure 3 An elastic, soft, pedunculated nodule 12 mm in diameter was detected on the left tongue margin (arrow).

Figure 4 No malignancy was reported nor were there any inclusion bodies suggestive of cytomegalovirus infection. A: Histological examination of the excised tongue nodule showing granulation tissue with capillaries and fibroblasts (Hematoxylin-eosin stain × 20, bar = 500 µm); B: Moderate infiltration with inflammatory cells, notably neutrophils. There was no malignancy or inclusion bodies suggestive of cytomegalovirus infection (Hematoxylin-eosin, × 200, bar = 50 µm).

Figure 5 We observed no recurrence of the lesion at 1 year and 5 mo after the procedure.