Liver involvement in the drug reaction, eosinophilia, and systemic symptoms syndrome

Figure 1 Diagnostic algorithm of drug reaction, eosinophilia, and systemic symptoms syndrome / drug-induced hypersensitivity syndrome case series. ALT: Alanine aminotransaminase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; BALP: Broncho-alveolar lavage fluid; BG: Blood gasses; cB: Conjugated bilirubin; cdefects: Conduction defects; CPK: Creatine phosphokinase; CPK-2/MB: Creatine phosphokinase for heart muscle involvement; CPK-3/CPK-MM: Creatine phosphokinase for skeletal muscle involvement; creaCl: Creatinine clearance; CT: Computed tomography; CXR: Chest-x-ray; ECG: Electrocardiogram; ECHO: Echocardiogram; EMG: Electromyography; EM: Endomyocardial; HP: Histopathology; MRI; TB: Total bilirubin; UNL: Upper normal limit. ¹The RegiSCAR criteria should be done to potential cases of DReSS for more accurate diagnosis and classification (see Table 1). ²Organ involvement after exclusion of other explanations.