Expression and predictive value of miR-489 and miR-21 in melanoma metastasis

Figure 1 Comparison of relative expression of serum miR-489 and miR-21 between the research group and control group. A: The expression of miR-489 in the research group was significantly lower than that in the control group (P < 0.001). B: The expression of mir-21 in the research group was significantly higher than that in the control group (P < 0.001). ^cP < 0.001.

Figure 2 ROC curves of serum miR-489 and miR-21 for diagnosis of melanoma metastasis. A: The sensitivity and specificity of serum miR-9a were, respectively, 75.56% and 80.00%. B: The sensitivity and specificity of serum miR-133b were, respectively, 77.78 and 82.22%.

Figure 3 Correlation between relative expression of miR-489 and miR-21 in serum and TNM stage of melanoma in the research group. A: The relative expression of serum miR-489 decreased with the increase of TNM stage (P < 0.05). ^aP < 0.05; ^cP < 0.001. B: The relative expression of serum miR-21 increased with the increase of TNM stage (P < 0.05). ^aP < 0.05; ^cP < 0.001. C: The relative expression of serum miR-489 was negatively correlated with TNM stage (r = -0.612, P < 0.001). D: The relative expression of serum miR-21 was positively correlated with TNM stage (r = 0.609, P < 0.001).