Characteristics of multiple nodules in a patient with pulmonary Langerhans cell histiocytosis: A case report

Figure 1 Radiological findings at the initial diagnosis. A: Chest X-ray at the diagnosis showed multiple nodules in bilateral lung fields; B and C: Chest computed tomography showed multiple nodules, adjacent to the pleura or bronchus, predominantly in the right lower lobe. Some small nodules showed cystic formation (arrow); D: Largest nodule was in the right middle lobe; 22 mm dia. (arrow). Arrowhead: A dilated bronchus, but not a cystic nodule.

Figure 2 Histopathological findings obtained from a nodule in right lower field. A and B: Hematoxylin-eosin staining showing abnormal cells with notched nuclei with the infiltration of many eosinophils; C and D: Abnormal cells were positive for CD1a and S-100.

Figure 3 Radiological findings at 6 mo after the patient quit smoking. A: Chest X-ray; B: Computed tomography scan.

Figure 4 Numbers and sizes of cystic and non-cystic nodules. A: Number of nodules in each lobe. The prevalence of cystic nodules is compared. ^aP<0.01 vs the right upper lobe, ^cP < 0.01 vs the left upper lobe; B: Sizes of the nodules. The data summarize the results of all lung lobes. ^fP < 0.0001 vs the cystic nodules.