Bilateral and symmetric C1-C2 dumbbell ganglioneuromas associated with neurofibromatosis type 1: A case report

Figure 1 Preoperative magnetic resonance images of the patient. A: Axial T1-weighted image shows bilateral dumbbell masses displaying low signal (arrows); B and D: Axial and coronal T2-weighted images show bilateral dumbbell masses displaying high signal (arrows); C and E: Axial and sagittal T1-weighted images after administration of gadolinium-diethylenetriaminepentaacetic acid depict prominent heterogeneous enhancement of the lesions (contrast dose: 15 mL: 7.04 g) (arrows).

Figure 2 Histopathology of the resected lesion. A: Hematoxylin and eosin staining showing spindle-shaped tumor cells, fusiform nuclei, and ganglion cells scattered in the tumor tissue (arrow). B-F: Immunohistochemistry showing Ki-67 (1%+) (B), NeuN (Scattered+) (C), NF (Scattered+) (D), S-100 (+) (E), and Vimentin (+) (F) (arrows).

Figure 3 Postoperative magnetic resonance images of the patient. Axial T1-weighted image (A), axial and coronal T2-weighted images (B and D), and axial and sagittal contrast-enhanced T1-weighted images (C and E) showing no evidence of recurrence (arrows).