Idiopathic hypereosinophilic syndrome presenting with severe vasculitis successfully treated with imatinib

Figure 1 Bone marrow biopsy. A: Hematoxylin and eosin (H and E)-stained section of paraffin-embedded bone marrow showing expansion of the myeloid cellular line with marked increase in granulated eosinophilic cells (100 ×); B: High-power view of the diffuse eosinophilic infiltration (white arrows), without any detectable morphological signs of abnormal proliferation (400 ×).

Figure 2 Brain magnetic resonance imaging showed multiple small focal lesions, with the most serious in the occipital regions and others in the frontal areas. A: Diffusion weighted imaging was consistent with ischemic multiple lesions; B: Spontaneous hyperintensity in T1, indicating blood suffusions and suggestive of vasculitis. Following this magnetic resonance imaging, the patient performed a campimetric exam that showed an asymmetric bilateral visual loss, which did not ever completely resolve despite therapy.