Suspected donepezil withdrawal syndrome in an older woman with Alzheimer disease of abrupt cessation: A case report

Figure 1 Clinical course timeline (day 0 = abrupt discontinuation of donepezil 10 mg/day at nursing-home admission). Dark-gray bar: Donepezil 10 mg before discontinuation; light-gray bar: Donepezil 5 mg after rechallenge on day 7. Medium-gray bar: As-needed quetiapine 125 mg during the symptomatic/rechallenge period. Grey bars indicate symptom periods reconstructed from the clinical record. Confusion assessment method was positive on day 2 to 3. The timeline is aligned with Table 2; symptom intervals are based on retrospective chart documentation and are not standardized severity measurements. The figure has been converted to grayscale to improve accessibility for readers with color-vision deficiency. Confusion assessment method; PRN: Pro re nata.