Herbal medicine for mild cognitive impairment: Neuroimaging perspectives

doi:10.12998/wjcc.v14.i16.118410

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Cases. Jun 6, 2026; 14(16): 118410
Published online Jun 6, 2026. doi: 10.12998/wjcc.v14.i16.118410

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Figure 1 Mechanistic framework of herbal medicine in mild cognitive impairment. Herbal medicine exerts multi-target effects in mild cognitive impairment through four key pathways: Neuroprotection and anti-inflammation, cholinergic modulation, improved cerebral metabolism and perfusion, and gut-brain axis regulation. These mechanisms collectively influence brain structure, function, and metabolism, as reflected by multimodal neuroimaging biomarkers. IL-6: Interleukin-6; TNF-α: Tumour necrosis factor alpha; ROS: Reactive oxygen species; ACh: Acetylcholine; BDNF: Brain-derived neurotrophic factor; NGF: Nerve growth factor.

Citation: Zhang YQ. Herbal medicine for mild cognitive impairment: Neuroimaging perspectives. World J Clin Cases 2026; 14(16): 118410
URL: https://www.wjgnet.com/2307-8960/full/v14/i16/118410.htm
DOI: https://dx.doi.org/10.12998/wjcc.v14.i16.118410

Zhang YQ. Herbal medicine for mild cognitive impairment: Neuroimaging perspectives. World J Clin Cases 2026; 14(16): 118410 [DOI: 10.12998/wjcc.v14.i16.118410]

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