Expression rates of p16, p53 in head and neck cutaneous squamous cell carcinoma based on human-papillomavirus positivity

Figure 1 Classification of tumor location into high-risk and mid-risk zones. Area H (yellow area) encompasses central facial regions, including eyelids, eyebrows, periorbital area, nose, lips, chin, mandible, preauricular, and postauricular areas; area M (blue area) includes the cheeks, forehead, and scalp.

Figure 2 Representative images of immunohistochemical study are shown. A: Images of human papillomavirus staining, negative (× 200); B: Images of human papillomavirus staining, positive (× 400); C: Images of p16 staining, negative (× 200); D: Images of p16 staining, positive (× 200); E: Images of p53 staining, negative (× 200); F: Images of p53 staining, positive (× 200).