Genetic insights in infectious diseases: Insights from a case report and implications for personalized medicine

Figure 1 This figure illustrates the key steps involved in conducting a genome-wide association study, which aims to identify genetic variants associated with specific traits, such as height.

Figure 2 Detailed role of vitamin D receptor in immune response and elaborated role of solute carrier family 11 member 1 in immune response. A: This flowchart illustrates the activation and immune modulation pathways of vitamin D receptor, from vitamin D receptor activation to its role in innate and adaptive immunity, secretion of antibacterial peptides, and implications for disease susceptibility and immune dysregulation; B: This flowchart highlights the role of solute carrier family 11 member 1 in macrophage-mediated iron regulation, pathogen suppression, and the downstream effects of genetic polymorphisms on resistance to infections and drug resistance. VDR: Vitamin D receptor; VDRE: Vitamin D response elements; SLC11A1: Solute carrier family 11 member 1.

Figure 3 This figure illustrates the interaction between specific genes and their associated diseases, highlighting the role of these genetic factors in influencing disease susceptibility, progression, and treatment outcomes. HMOX1: Heme-oxygenase 1; SLC11A1: Solute carrier family 11 member 1; VDR: Vitamin D receptor; HIV: Human immunodeficiency virus; TB: Tuberculosis.

Figure 4 This figure outlines the key steps involved in metagenomic next-generation sequencing.