C634Y mutation in RET-induced multiple endocrine neoplasia type 2A: A case report

Figure 1 Bilateral adrenal computed tomography scans. A: Contrast-enhanced bilateral adrenal computed tomography scans of proband IIa. Space-occupying lesions of the bilateral adrenal masses were observed; B: Non-contrast enhanced + contrast-enhanced bilateral adrenal computed tomography scans of patient Ib.

Figure 2 Thyroid B-ultrasound. A: Proband IIa. Bilateral thyroid nodules were observed (10 mm × 4 mm); B: Patient Ib. A hypoechoic nodule (16 mm × 11 mm) was observed in the right thyroid.

Figure 3 Bilateral thyroid pathology of patient Ib. Medullary thyroid carcinoma was observed.

Figure 4 Pedigree chart of the family.

Figure 5 DNA sequencing showing the mutation characterized by a nucleotide (c. T1901A) and an amino acid (p.Cys634Tyr) change in the family members.