Efficacy of abatacept treatment in a patient with enteropathy carrying a variant of unsignificance in CTLA4 gene: A case report

Figure 1 Endoscopic examinations. A: After performing a gastroduodenoscopy, erosive gastritis was observed. The mucosa in the bulbous and 2^nd part of the duodenum was edematous and nodular; B: After performing a colonoscopy, we found that the severity was variable, the mucosa in all colon segments, including the rectum, was edematous and hyperemic, the vascular structure was lost, it was sensitive to the touch, and erosion and ulceration had occurred in places. The ulcers were millimeter in size, superficial and covered with exudate.

Figure 2 Panoramic view of colonic mucosa. A: Arrows point to the enlarged and increased number of lymphoid follicles (lymphoid hyperplasia) (HE, 2×). No atypia of lymphoid cells was noted. The lamina propria expanded with the infiltration of immune cells, such as lymphocytes, plasma cells, and macrophages. The number of crypts diminished focally (HE, 20×); B: The arrows point to the increased crypt epithelial apoptosis in a Graft-versus-Host Disease-like pattern. The lamina propria expanded with predominantly mononuclear inflammatory cell infiltration (HE, 200×).