Hepatic epithelioid hemangioendothelioma: Clinical characteristics, diagnosis, treatment, and prognosis

Figure 1 Abdominal computed tomography of case one. A and B: Computed tomography (CT) showed two round low-density nodules in the right lobe of the liver; C and D: Contrast-enhanced CT showed that the peripheral rim of the nodules was enhanced.

Figure 2 Immunohistochemical staining of case one. A: Positivity for CD34 in case one (magnification, × 200); B: Positivity for vimentin in case one (magnification, × 200); C: Positivity for Ki-67 in case one (magnification, × 200); D: Positivity for smooth muscle actin in case one (magnification, × 200).

Figure 3 Abdominal computed tomography of case two. A: Computed tomography showed multiple hypodense hepatic nodular formations, all of which were slightly enhanced during the arterial phase; B: After four cycles of transhepatic arterial chemotherapy and embolization, the number of lesions increased; C-F: After 18 mo of interferon treatment, the lesions were gradually reduced and disappeared.

Figure 4 Search and selection process. CNKI: China National Knowledge Infrastructure.

Figure 5 Abdominal computed tomography of hepatic epithelioid hemangioendothelioma. A: Target sign (black arrow) and lollipop sign (red arrow); B: Capsular retraction (black arrow).

Figure 6 Overall survival of patients with hepatic epithelioid hemangioendothelioma. A-C: Overall survival according to liver function (A), intrahepatic metastasis (B), and treatment (C). OS: Overall survival.