Autophagy-related long non-coding RNA prognostic model predicts prognosis and survival of melanoma patients

Figure 1 Co-expression network construction using 15 lncRNAs with Cytoscape. A: Cytoscape network; B: Sankey diagram for lncRNA visualization.

Figure 2 Survival analysis of 15 autophagy-associated lncRNAs. A: AC004687.1; B: AC011374.2; C: AC018553.1; D: AC068282; E: AC090948.3; F: AC242842.1; G: AL133371.2; H: DBH−AS1; I: HLA−DQB1−AS1; J: ITGB2−AS1; K: LINC00324; L: LINC00520; M: USP30−AS1; N: PCED1B−AS1; O: LINC01943. (Red and blue represent the high and low expression of the lncRNAs in melanoma patients, respectively).

Figure 3 Prognostic value of the 15-lncRNA risk model for melanoma. A: Survival rate analysis; B: Representative risk curve showing the risk scores; C: Scatter diagram of survival state. Green dots: Surviving; red dots: Dead; D: Representative heatmap showing the expression of indicated lncRNAs in different groups. Green and red represent low and high expression, respectively.

Figure 4 Melanoma risk model evaluation. A and B: Univariate and multivariate Cox regression analyses for prognostic risk scores and different clinical features; C: Receiver operating characteristic curves for risk scores and different clinical characteristics (age, gender, and TMN stage).

Figure 5 Gene Set Enrichment Analysis for functional enrichment analysis of 15 autophagy-related lncRNAs. Among them, Gene Ontology, KEGG pathway, and immune signal were significantly enriched in the low-risk group, while the KEGG pathway was slightly enriched in the high-risk group. A: Enrichment plot: GOBP_DEFENSE_RESPONSE_TO_VIRUS; B: GOBP_INTERLEUKIN_8_PRODUCTION; C: GOBP_RESPONSE_TO_INTERFERON_GAMMA; D: GOBP_RESPONSE_TO_VIRUS; E: KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION; F: KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM; G: KEGG_LEISHMANIA_INFECTION; H: KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS; I: KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.