Luo L, Li YX. Pulmonary Langerhans cell histiocytosis and multiple system involvement: A case report. World J Clin Cases 2021; 9(35): 11029-11035 [PMID: 35047614 DOI: 10.12998/wjcc.v9.i35.11029]
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05361570
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December 29, 2021, 15:56
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Reader Comments:
I read with great interest this article. Langerhans cell histiocytosis (LCH) is a rare disorder that can involve different organs, rarely just the lungs. Pulmonary involvement primarily affects young adults with cigarette smoking attitude, however the peculiarity of this case is the complete absence of history of smoking. Lung CT images reported in this article are not representative for Langerhans cell histiocytosis. CT features indicative for LCH are represented by multiple small nodules with blurred boundaries in both lungs, and cystic changes. Multiple pathologies can mimic these kind of lesions such as metastatic lung involvement, sarcoidosis, silicosis and tuberculosis, however in this case an organizing pneumonia can be suspected too, according to the presence of multiple proliferative lesions in both lungs, similar to inflammation, with blurred boundaries. For this reason a thoracoscopic lung biopsy is necessary to confirm pulmonary Langerhans cell histiocytosis, as in this case. In conclusion LCH can be a challenging issue that need a wide knowledge of this disease to be correctly diagnosticated and managed.
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