Cappellani F, Capobianco M, Leonforte F, Avitabile A, Visalli F, Khouyyi M, Giglio R, Inferrera L, Tognetto D, D’Esposito F, Gagliano C, Zeppieri M. Underlying cause of diabetic retinopathy: Metabolic instability. World J Clin Cases 2026; 14(12): 120247 [DOI: 10.12998/wjcc.v14.i12.120247]
Reader's ID:
02625110
Submitted on:
April 16, 2026, 09:10
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Reader Comments:
the article raises new paradigm in understanding the mechanisms that lead to DR in all types of diabetic patients pointing to the false or invalid dependence of conventional glucose biomarkers rather than looking to the glycemic instabiliuty as the major contributing factor that leads to DR.
the article did not discuss if this will have an impact on the prediabetic state or only glycemic instability effects apply to overt diabetic states.
the article included details of limitations and future prospective that will enhance future research.
Author's Reply:
Replied on April 17, 2026, 12:13
Many thanks for the comments about our paper. We will address the valid point in our future study, which is currently being prepared.