©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Methodol. Dec 26, 2015; 5(4): 223-229
Published online Dec 26, 2015. doi: 10.5662/wjm.v5.i4.223
Published online Dec 26, 2015. doi: 10.5662/wjm.v5.i4.223
Forkhead box protein A2 and T helper type 2-mediated pulmonary inflammation
Ling Sun, Xiao-Ju Tang, Laboratory of Cardiovascular Diseases Research Center of Regeneration Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Feng-Ming Luo, Department of Pulmonary Diseases, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Feng-Ming Luo, Department of Family Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Sun L and Tang XJ generated the figures and wrote the manuscript; Luo FM designed the aim of the editorial and wrote the manuscript.
Supported by The National Natural Science Foundation of China, Nos. 30871118, 30971325, 81270129 and 81470268 (FL); and grants from Department of Science and Technology of Sichuan Province, Nos. 09ZQ026-020 and 2009SZ0190 (FL).
Conflict-of-interest statement: None.
Correspondence to: Feng-Ming Luo, MD, PhD, Department of Family Medicine, West China Hospital, Sichuan University, 37 GuoXue Xiang, Chengdu 610041, Sichuan Province, China. luofengming@hotmail.com
Telephone: +86-28-85422759 Fax: +86-28-85422788
Received: January 29, 2015
Peer-review started: January 30, 2015
First decision: March 6, 2015
Revised: March 24, 2015
Accepted: September 29, 2015
Article in press: September 30, 2015
Published online: December 26, 2015
Processing time: 319 Days and 17.6 Hours
Peer-review started: January 30, 2015
First decision: March 6, 2015
Revised: March 24, 2015
Accepted: September 29, 2015
Article in press: September 30, 2015
Published online: December 26, 2015
Processing time: 319 Days and 17.6 Hours
Core Tip
Core tip: The transcription factor forkhead box protein A2 (FOXA2) plays pivotal roles in embryonic development and organogenesis. Conditional deletion of FOXA2 in airway epithelial cells during the early stage of lung development will result in abnormal morphology of the lung and T helper type 2-mediated pulmonary inflammation. In addition, FOXA2 regulates the goblet cell differentiation during lung development and in pulmonary diseases such as asthma and chronic obstructive pulmonary disease. FOXA2 may be a new target for the treatment of lung disease.