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World J Methodol. Sep 20, 2026; 16(3): 116914
Published online Sep 20, 2026. doi: 10.5662/wjm.116914
Published online Sep 20, 2026. doi: 10.5662/wjm.116914
Letter to the Editor: Low-energy fractional carbon dioxide laser priming of mesenchymal stem cell-derived exosomes: A photothermal boost for diabetic wound angiogenesis
Xu-Jin Wu, Department of Orthopedics (Hand and Foot Surgery), Affiliated Xiaoshan Hospital, Hangzhou Normal University, Hangzhou 311200, Zhejiang Province, China
Ju-Yu Tang, Nian-Zhe Sun, National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China
Ju-Yu Tang, Nian-Zhe Sun, Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China
Co-corresponding authors: Ju-Yu Tang and Nian-Zhe Sun.
Author contributions: Wu XJ wrote the first draft, developed the main ideas, and led the revisions; Sun NZ and Tang JY provided critical feedback, improved the structure, and added key examples, and they have played important and indispensable roles in the manuscript preparation as the co-corresponding authors.
AI contribution statement: Only DeepL was used to revise the language, grammar and sentence order of the manuscript. No AI tools such as ChatGPT and Grammarly were adopted in the whole research and writing process.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Nian-Zhe Sun, MD, PhD, National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Kaifu District, Changsha 410008, Hunan Province, China. sunnzh201921@sina.com
Received: November 25, 2025
Revised: January 9, 2026
Accepted: January 22, 2026
Published online: September 20, 2026
Processing time: 228 Days and 7.2 Hours
Revised: January 9, 2026
Accepted: January 22, 2026
Published online: September 20, 2026
Processing time: 228 Days and 7.2 Hours
Core Tip
Core Tip: Chen et al demonstrate that fractional carbon dioxide laser-induced photothermal stimulation enhances the biological activity of mesenchymal stem cell-derived exosomes by enriching sphingosine-1-phosphate content and activating the S1PR1/AKT/HIF-1α pathway. These laser-activated exosomes significantly promote endothelial angiogenesis and accelerate diabetic wound healing in vivo. This study introduces a safe, controllable, and clinically accessible strategy for optimizing exosome-based acellular therapies in chronic diabetic wounds.