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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Methodol. Mar 20, 2026; 16(1): 112458
Published online Mar 20, 2026. doi: 10.5662/wjm.v16.i1.112458
Published online Mar 20, 2026. doi: 10.5662/wjm.v16.i1.112458
Are iris masses in lung carcinoma always a metastasis: Two case reports
Bhagabat Nayak, Koyel Chakraborty, Jayadev Nanda, Shri Haripriya, Bijnya Birajita Panda, Department of Ophthalmology, All India Institute of Medical Sciences, Bhubaneshwar 751019, Odisha, India
Prasanta Raghab Mohapatra, Department of Pulmonary Medicine, All India Institute of Medical Sciences, Bhubaneshwar 751019, Odisha, India
Satya Padmaja Mantha, Department of Pulmonary Medicine and Critical Care, All India Institute of Medical Sciences, Bhubaneshwar 751019, Odisha, India
Madhusmita Sethy, Department of Pathology, All India Institute of Medical Sciences, Bhubane
Author contributions: Nayak B, Mohapatra PR, Chakraborty K, Nanda J, Mantha SP, Sethy M contributed to manuscript writing and editing, and data collection; Nayak B, Chakraborty K, Nanda J, Haripriya S, Panda BB contributed to data analysis; Nayak B, Mohapatra PR contributed to conceptualization and supervision; all authors have read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bijnya Birajita Panda, Assistant Professor, Department of Ophtha
Received: July 28, 2025
Revised: September 1, 2025
Accepted: November 14, 2025
Published online: March 20, 2026
Processing time: 197 Days and 20.9 Hours
Revised: September 1, 2025
Accepted: November 14, 2025
Published online: March 20, 2026
Processing time: 197 Days and 20.9 Hours
Core Tip
Core Tip: Though iris metastasis is rare in cases of systemic malignancies, a relatively rich vascular supply of uveal tissue makes it vulnerable compared to other ocular structures. Iris masses are often unilateral, may be painful and are vision-threatening. The lesion can be single or multiple, usually well-defined, inducing anterior chamber reaction leading to secondary glaucoma. With treatment advances like platinum doublet chemotherapy and targeted therapy for specific mutations, the disease progression can be arrested with alleviation of symptoms. However, some cases may require surgical intervention to manage the complications.