White blood cells and neutrophil-to-high density lipoprotein ratio as predictive markers of left ventricular dysfunction in heart failure

doi:10.5662/wjm.v16.i1.108178

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World Journal of Methodology

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2222-0682

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World J Methodol. Mar 20, 2026; 16(1): 108178
Published online Mar 20, 2026. doi: 10.5662/wjm.v16.i1.108178

White blood cells and neutrophil-to-high density lipoprotein ratio as predictive markers of left ventricular dysfunction in heart failure

Pradeep Kumar Dabla, Dharmsheel Shrivastav, Vimal Mehta, Swati Singh, Rashid Mir

Pradeep Kumar Dabla, Department of Biochemistry, Govind Ballabh Pant Institute of Postgraduate Medical Education, New Delhi 110002, India

Dharmsheel Shrivastav, Department of Biochemistry, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, Associated Maulana Azad Medical College, New Delhi 110002, India

Dharmsheel Shrivastav, Department of Biochemistry, Noida International University, Noida 203201, Uttar Pradesh, India

Vimal Mehta, Department of Cardiology, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi 110002, India

Swati Singh, Department of Biochemistry, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi 110002, India

Rashid Mir, Department of Medical Lab Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, India

Author contributions: Dabla PK designed the study; Dabla PK and Shrivastav D analyzed the manuscript; Dabla PK provided facilities for biochemical testing and Mehta V provided the facility for the enrollment of patients; Shrivastav D and Singh S drafted the manuscript; Dabla PK, Mehta V and Mir R critically reviewed the manuscript and contributed in finalization of the manuscript analysis; all authors reviewed and approved the manuscript.

Institutional review board statement: All procedures performed in this study involving human participants were conducted in accordance with the ethical standards of the Institutional Ethics Committee of Maulana Azad Medical College and associated hospitals, New Delhi, India (Approval No. F1/IEC/MAMC/85/03/21/No. 422; Date: 30.08.2021), and with the 1964 Helsinki declaration and its later amendments.

Informed consent statement: Written informed consent was taken from all participants included in the study.

Conflict-of-interest statement: The authors declare that they have no conflicts of interest.

STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement- checklist of items.

Data sharing statement: Data is available from the corresponding author on request.

Corresponding author: Pradeep Kumar Dabla, MD, Professor, Department of Biochemistry, Govind Ballabh Pant Institute of Postgraduate Medical Education, JLN Marg, New Delhi 110002, India. pradeep.dabla@gmail.com

Received: April 8, 2025
Revised: June 7, 2025
Accepted: September 1, 2025
Published online: March 20, 2026
Processing time: 308 Days and 21.7 Hours

Core Tip

Core Tip: Literature has established white blood cells (WBC) as a key player in the inflammatory response, including ventricular remodeling and interstitial fibrosis. Several studies have demonstrated that WBC differentials such as lymphocytes and neutrophils and neutrophil-to-high density lipoprotein ratio are linked to heart failure (HF) development, particularly, in patients with low left ventricular ejection fraction (LVEF). In the present study, we explore the association between these parameters and LVEF, focusing on their predictive potential in HF.