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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Methodol. Mar 20, 2026; 16(1): 107426
Published online Mar 20, 2026. doi: 10.5662/wjm.v16.i1.107426
Published online Mar 20, 2026. doi: 10.5662/wjm.v16.i1.107426
Multiparametric magnetic resonance imaging in differentiating benign and malignant sinonasal masses: A prospective study and literature review
Manish Saini, Smita Manchanda, Ashu S Bhalla, Devasenathipathy Kandasamy, Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, New Delhi 110029, India
Aanchal Kakkar, Department of Pathology, All India Institute of Medical Sciences, New Delhi 110029, India
Alok Thakar, Department of Otorhinolaryngology and Skull Base Surgery, All India Institute of Medical Sciences, New Delhi 110029, India
Author contributions: Saini M designed the research study; was involved in the data acquisition, collection, and analysis; and wrote the first draft of the manuscript; Manchanda S designed the research study, collected the data, and wrote and edited the manuscript; Bhalla AS and Kandasamy D designed the research study and reviewed and edited the manuscript; Kakkar A and Thakar A reviewed and edited the manuscript; All authors have read and approved the final manuscript.
Institutional review board statement: All procedures performed in the study were in accordance with the ethical standards of the institute and were preapproved by the Institute Review Board (No. IECPG-487/25.08.2021).
Informed consent statement: Informed consent was obtained from all individual participants included in the study.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement- checklist of items.
Data sharing statement: All data and materials are available from the corresponding author, upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Smita Manchanda, MD, Professor, Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India. smitamanchanda@gmail.com
Received: March 24, 2025
Revised: April 28, 2025
Accepted: June 19, 2025
Published online: March 20, 2026
Processing time: 324 Days and 15.9 Hours
Revised: April 28, 2025
Accepted: June 19, 2025
Published online: March 20, 2026
Processing time: 324 Days and 15.9 Hours
Core Tip
Core Tip: We studied the role of advanced magnetic resonance imaging techniques in the evaluation of sinonasal masses. The mean apparent diffusion coefficient derived from conventional diffusion-weighted imaging (DWI) can serve as an imaging marker to differentiate between benign and malignant sinonasal masses. Other imaging parameters such as the true diffusion coefficient from intravoxel incoherent motion imaging (IVIM), kurtosis coefficient, and diffusion coefficient from diffusion kurtosis imaging (DKI) were also statistically significant. However, there was no incremental benefit of DKI and IVIM over conventional DWI. Perfusion parameters also did not show any significant difference.