Systematic Reviews
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Methodol. Dec 20, 2025; 15(4): 102408
Published online Dec 20, 2025. doi: 10.5662/wjm.v15.i4.102408
Navigating gastrointestinal challenges in genetic myopathies: Diagnostic insights and future directions
Mohammed Al-Beltagi, Nermin Saeed, Adel Bediwy, Reem Elbeltagi
Mohammed Al-Beltagi, Department of Paediatrics, Faculty of Medicine, Tanta University, Tanta 31511, Alghrabia, Egypt
Mohammed Al-Beltagi, Department of Pediatric, University Medical Center, King Abdulla Medical City, Arabian Gulf University, Manama 26671, Bahrain
Nermin Saeed, Department of Pathology, Medical Microbiology Section, Salmaniya Medical Complex, ‎Governmental Hospitals, Manama 12, Bahrain
Nermin Saeed, Department of Pathology, Medical Microbiology Section, The Royal College of Surgeons in Ireland-Bahrain, Busaiteen 15503‎, Muharraq, Bahrain
Adel Bediwy, Department of Pulmonology, Faculty of Medicine, Tanta University, Tanta 31527, Alghrabia, Egypt
Adel Bediwy, Department of Pulmonology, University Medical Center, King Abdulla Medical City, Arabian Gulf University, Manama 26671, Bahrain
Reem Elbeltagi, Department of Medicine, The Royal College of Surgeons in Ireland-Bahrain, Busaiteen 15503, Muharraq, Bahrain
Author contributions: Al-Beltagi M conceptualized and designed the study, conducted the literature search, and wrote the initial draft of the manuscript; Saeed N contributed to data extraction, quality assessment, and critical revision of the manuscript; Bediwy A assisted in data synthesis, statistical analysis, and manuscript editing; Elbeltagi R contributed to manuscript formatting, reference management, and final proofreading; all authors reviewed and approved the final version of the manuscript.
Conflict-of-interest statement: The authors declare no conflicts of interest related to this study. No financial, personal, or professional relationships influenced the research, analysis, or manuscript preparation.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mohammed Al-Beltagi, MD, PhD, Professor, Department of Paediatrics, Faculty of Medicine, Tanta University, El Bahr Street, Tanta 31511, Alghrabia, Egypt. mbelrem@hotmail.com
Received: October 16, 2024
Revised: February 21, 2025
Accepted: February 27, 2025
Published online: December 20, 2025
Processing time: 292 Days and 1.4 Hours
Core Tip

Core Tip: Gastrointestinal (GI) manifestations in genetic myopathies are frequently overlooked yet significantly impact patient outcomes. This systematic review highlights the prevalence, diagnostic challenges, and management strategies for GI dysfunction in conditions like Duchenne muscular dystrophy, Becker muscular dystrophy, and mitochondrial myopathies. The study underscores the role of imaging, motility testing, and genetic evaluation in guiding care. Additionally, it explores the influence of genetic and environmental modifiers on symptom variability. A multidisciplinary approach integrating gastroenterology, neurology, and nutrition is essential for improving quality of life. Future research should focus on targeted therapies and molecular mechanisms to optimize patient management.